Literature DB >> 6330997

Mouse mammary tumor virus DNA methylation: tissue-specific variation.

T Breznik, V Traina-Dorge, M Gama-Sosa, C W Gehrke, M Ehrlich, D Medina, J S Butel, J C Cohen.   

Abstract

Mouse mammary tumor virus-specific DNA sequences endogenous to the BALB/c mouse are shown to exhibit variable levels of methylation in a tissue-specific manner. In DNA from both lactating mammary gland and spleen, MMTV-specific sequences were hypomethylated at specific HpaII and HhaI sites. These variably methylated sites were found in the terminal repetitive sequences of the endogenous viral genomes. The specific hypomethylation of a HpaII site in Mtv-9 is associated with expression of a 1.6 kb transcript in the lactating mammary gland.

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Year:  1984        PMID： 6330997     DOI： 10.1016/0042-6822(84)90248-4

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  4 in total

1.  Repetitive sequence environment distinguishes housekeeping genes.

Authors:  C Daniel Eller; Moira Regelson; Barry Merriman; Stan Nelson; Steve Horvath; York Marahrens
Journal:  Gene       Date:  2006-10-05       Impact factor: 3.688

2.  Differential expression of endogenous mouse mammary tumor virus genes during development of the BALB/c mammary gland.

Authors:  J E Knepper; D Medina; J S Butel
Journal:  J Virol       Date:  1986-08       Impact factor: 5.103

3.  Two regions of the mouse mammary tumor virus long terminal repeat regulate the activity of its promoter in mammary cell lines.

Authors:  P Lefebvre; D S Berard; M G Cordingley; G L Hager
Journal:  Mol Cell Biol       Date:  1991-05       Impact factor: 4.272

4.  Identification and characterization of a mouse mammary tumor virus protein uniquely expressed on the surface of BALB/cV mammary tumor cells.

Authors:  B L Slagle; J S Butel
Journal:  Virology       Date:  1985-05       Impact factor: 3.616
  4 in total

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