Literature DB >> 6330362

Steroidogenesis inhibitors. 1. Adrenal inhibitory and interceptive activity of trilostane and related compounds.

R G Christiansen, H C Neumann, U J Salvador, M R Bell, H P Schane, J E Creange, G O Potts, A J Anzalone.   

Abstract

Several methylated derivatives of trilostane were prepared. Methylation of C-4 or C-4 and C-17 changes this relatively selective adrenal inhibitor to compounds with increased ovarian/placental inhibitory activity with decreased adrenal inhibitory activity.

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Year:  1984        PMID： 6330362     DOI： 10.1021/jm00373a021

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  3 in total

Review 1.  Selective inhibition of human 3β-hydroxysteroid dehydrogenase type 1 as a potential treatment for breast cancer.

Authors:  James L Thomas; Kevin M Bucholtz; Balint Kacsoh
Journal:  J Steroid Biochem Mol Biol       Date:  2010-08-22       Impact factor: 4.292

2.  Structural basis for the selective inhibition of human 3beta-hydroxysteroid dehydrogenase 1 in human breast tumor MCF-7 cells.

Authors:  James L Thomas; Kevin M Bucholtz; Jingping Sun; Vance L Mack; Balint Kacsoh
Journal:  Mol Cell Endocrinol       Date:  2008-10-08       Impact factor: 4.102

3.  Structure/function of the inhibition of human 3beta-hydroxysteroid dehydrogenase type 1 and type 2 by trilostane.

Authors:  James L Thomas; Vance L Mack; Jason A Glow; Delaram Moshkelani; J Ross Terrell; Kevin M Bucholtz
Journal:  J Steroid Biochem Mol Biol       Date:  2008-05-03       Impact factor: 4.292
  3 in total

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