Literature DB >> 6330148

Induction of generalized and lethal herpesvirus infection in the tree shrew by intrahepatic transfection of herpes simplex virus DNA.

G Darai, A Rösen, J Scholz, H Gelderblom.   

Abstract

The infectivity of herpes simplex virus (HSV) genome was investigated in vivo using the tree shrew, which is highly susceptible to HSV, as an animal model. Individual tree shrews were inoculated intrahepatically with 0.2 ml of a transfection mixture containing 25 micrograms HSV DNA, 50 micrograms salmon sperm DNA, and 250 micrograms DEAE-dextran. Seven out of nine tree shrews transfected with HSV DNA developed a generalized herpesvirus infection. The new virus progeny was found in different organs of transfected animals.

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Year:  1983        PMID： 6330148     DOI： 10.1016/0166-0934(83)90083-6

Source DB:  PubMed          Journal:  J Virol Methods        ISSN： 0166-0934            Impact factor:   2.014


  11 in total

1.  Mapping of the deletion in the genome of HSV-1 strain HFEM responsible for its avirulent phenotype.

Authors:  A Rösen; G Darai
Journal:  Med Microbiol Immunol       Date:  1985       Impact factor: 3.402

2.  Herpes Simplex Virus 1 Infection of Tree Shrews Differs from That of Mice in the Severity of Acute Infection and Viral Transcription in the Peripheral Nervous System.

Authors:  Lihong Li; Zhuoran Li; Erlin Wang; Rui Yang; Yu Xiao; Hongbo Han; Fengchao Lang; Xin Li; Yujie Xia; Feng Gao; Qihan Li; Nigel W Fraser; Jumin Zhou
Journal:  J Virol       Date:  2015-10-28       Impact factor: 5.103

3.  Analysis and characterization of the complete genome of tupaia (tree shrew) herpesvirus.

Authors:  U Bahr; G Darai
Journal:  J Virol       Date:  2001-05       Impact factor: 5.103

4.  Tupaia CD81, SR-BI, claudin-1, and occludin support hepatitis C virus infection.

Authors:  Yimin Tong; Yongzhe Zhu; Xueshan Xia; Yuan Liu; Yue Feng; Xian Hua; Zhihui Chen; Hui Ding; Li Gao; Yongzhi Wang; Mark A Feitelson; Ping Zhao; Zhong-Tian Qi
Journal:  J Virol       Date:  2010-12-22       Impact factor: 5.103

5.  Transduction of virulence in herpes simplex virus type 1 from a pathogenic to an apathogenic strain by a cloned viral DNA fragment.

Authors:  A Rösen; H Gelderblom; G Darai
Journal:  Med Microbiol Immunol       Date:  1985       Impact factor: 3.402

6.  Investigation of the virulence genes of herpes simplex virus 2 by experimental infection in vivo with defined intertypic recombinants of a virulent HSV-2 X an avirulent HSV-1.

Authors:  A Rösen; G Darai
Journal:  Med Microbiol Immunol       Date:  1985       Impact factor: 3.402

Review 7.  The tree shrew as a model for infectious diseases research.

Authors:  Runfeng Li; Mark Zanin; Xueshan Xia; Zifeng Yang
Journal:  J Thorac Dis       Date:  2018-07       Impact factor: 2.895

8.  Expression of human immunodeficiency virus type 1 gag gene using genetically engineered herpes simplex virus type 1 recombinants.

Authors:  A Rösen-Wolff; K Raab; L Zöller; G Darai; J Eberle; F Deinhardt
Journal:  Virus Genes       Date:  1990-12       Impact factor: 2.332

9.  Histopathological changes in the liver of tree shrew (Tupaia belangeri chinensis) persistently infected with hepatitis B virus.

Authors:  Ping Ruan; Chun Yang; Jianjia Su; Ji Cao; Chao Ou; Chengpiao Luo; Yanping Tang; Qi Wang; Fang Yang; Junlin Shi; Xiaoxu Lu; Linqun Zhu; Hong Qin; Wen Sun; Yuanzhi Lao; Yuan Li
Journal:  Virol J       Date:  2013-11-12       Impact factor: 4.099

10.  Characterization of hepatitis E virus infection in tree shrew (Tupaia belangeri chinensis).

Authors:  Wenhai Yu; Chenchen Yang; Yanhong Bi; Feiyan Long; Yunlong Li; Jue Wang; Fen Huang
Journal:  BMC Infect Dis       Date:  2016-02-16       Impact factor: 3.090
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