Literature DB >> 6329789

Inappropriate correction for radioactive decay in fully iodinated adrenergic radioligands.

V M Doyle, F R Bühler, E Bürgisser.   

Abstract

The present data demonstrate increased binding of various iodinated adrenergic radioligands. In contrast, this was not observed for [3H]dihydroalprenolol. This systematic deviation of apparent binding parameters can be explained by the inappropriate use of a decay correction factor, indicating that the decayed iodinated radioligands lose their binding ability. Consequently no correction for decay is required in the case of iodinated adrenergic radioligands.

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Year:  1984        PMID： 6329789     DOI： 10.1016/0014-2999(84)90146-8

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  5 in total

1.  Affinity of clenbuterol analogues for beta 2-adrenoceptors in bovine skeletal muscle and the effect of these compounds on urinary nitrogen excretion in female rats.

Authors:  M N Sillence; G G Pegg; D B Lindsay
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1991-10       Impact factor: 3.000

2.  Increased fat and skeletal muscle beta-adrenergic receptors but unaltered metabolic and hemodynamic sensitivity to epinephrine in vivo in experimental human thyrotoxicosis.

Authors:  S B Liggett; S D Shah; P E Cryer
Journal:  J Clin Invest       Date:  1989-03       Impact factor: 14.808

3.  Gene expression, localization, and characterization of endothelin A and B receptors in the human adrenal cortex.

Authors:  G Rossi; G Albertin; A Belloni; L Zanin; M A Biasolo; T Prayer-Galetti; M Bader; G G Nussdorfer; G Palù; A C Pessina
Journal:  J Clin Invest       Date:  1994-09       Impact factor: 14.808

4.  Direct relationship between mononuclear leukocyte and lung beta-adrenergic receptors and apparent reciprocal regulation of extravascular, but not intravascular, alpha- and beta-adrenergic receptors by the sympathochromaffin system in humans.

Authors:  S B Liggett; J C Marker; S D Shah; C L Roper; P E Cryer
Journal:  J Clin Invest       Date:  1988-07       Impact factor: 14.808

5.  Independent regulation of beta 1- and beta 2-adrenoceptors.

Authors:  M Beer; S Hacker; J Poat; S M Stahl
Journal:  Br J Pharmacol       Date:  1987-12       Impact factor: 8.739
  5 in total

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