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Literature DB >> 6329688

A region of extreme instability in the mitochondrial genome of yeast.

R Marotta, Y Colin, R Goursot, G Bernardi.

Abstract

About half of the spontaneous petite mutants produced by wild-type Saccharomyces cerevisiae strain B (as well as by several other strains) have the same defective mitochondrial genome. Its repeat unit is a segment, 2200 base pairs (bp) long, which derives from an excision between the origins of replication ori 2 and ori 7 of the wild-type genome, and contains a hybrid ori 2-ori 7 sequence. The spontaneous petites carrying this defective ori.h genome are supersuppressive , i.e., they very rapidly compete out the wild-type genome in crosses. The main reasons for the exceptional frequency of ori.h petites are an extremely high excision frequency, due to the extended homology between the two tandemly oriented ori sequences 265 bp long and the short distance separating them. Such an excision frequency is very strongly increased in petite genomes encompassing the ori 2-ori 7 region, because of their higher concentration in these ori sequences.

Entities: Chemical

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Year: 1982 PMID： 6329688 PMCID： PMC553083 DOI： 10.1002/j.1460-2075.1982.tb01204.x

Source DB: PubMed Journal: EMBO J ISSN： 0261-4189 Impact factor: 11.598

19 in total

1. Tetrazolium overlay technique for population studies of respiration deficiency in yeast.

Authors: M OGUR; R ST. JOHN; S NAGAI
Journal: Science Date: 1957-05-10 Impact factor: 47.728

2. The mitochondrial genome of wild-type yeast cells. V. Genome evolution.

Authors: A Prunell; H Kopecka; F Strauss; G Bernardi
Journal: J Mol Biol Date: 1977-02-15 Impact factor: 5.469

3. Mitochondrial genetics. V. Multifactorial mitochondrial crosses involving a mutation conferring paromomycin-resistance in Saccharomyces cerevisiae.

Authors: K Wolf; B Dujon; P P Slonimski
Journal: Mol Gen Genet Date: 1973-09-05

4. Separation and characterization of a satellite DNA from a yeast cytoplasmic "petite" mutant.

Authors: G Bernardi; F Carnevali; A Nicolaieff; G Piperno; G Tecce
Journal: J Mol Biol Date: 1968-11-14 Impact factor: 5.469

5. Genome instability in a region of human DNA enriched in Alu repeat sequences.

Authors: B Calabretta; D L Robberson; H A Barrera-Saldaña; T P Lambrou; G F Saunders
Journal: Nature Date: 1982-03-18 Impact factor: 49.962

6. Gene amplification in methotrexate-resistant mouse cells. I. DNA rearrangement accompanies dihydrofolate reductase gene amplification in a T-cell lymphoma.

Authors: C Tyler-Smith; T Alderson
Journal: J Mol Biol Date: 1981-12-05 Impact factor: 5.469

1. Elevated levels of petite formation in strains of Saccharomyces cerevisiae restored to respiratory competence. II. Organization of mitochondrial genomes in strains having high and moderate frequencies of petite mutant formation.

Authors: R J Evans; G D Clark-Walker
Journal: Genetics Date: 1985-11 Impact factor: 4.562

A region of extreme instability in the mitochondrial genome of yeast.

1. Tetrazolium overlay technique for population studies of respiration deficiency in yeast.

2. The mitochondrial genome of wild-type yeast cells. V. Genome evolution.

3. Mitochondrial genetics. V. Multifactorial mitochondrial crosses involving a mutation conferring paromomycin-resistance in Saccharomyces cerevisiae.

4. Separation and characterization of a satellite DNA from a yeast cytoplasmic "petite" mutant.

5. Genome instability in a region of human DNA enriched in Alu repeat sequences.

6. Gene amplification in methotrexate-resistant mouse cells. I. DNA rearrangement accompanies dihydrofolate reductase gene amplification in a T-cell lymphoma.

7. Extrachromosomal circular copies of the eukaryotic transposable element copia in cultured Drosophila cells.

8. The chloroplast genome of bleached mutants of Euglena gracilis.

9. The origins of replication of the yeast mitochondrial genome and the phenomenon of suppressivity.

10. Rapid purification of yeast mitochondrial DNA in high yield.

1. Elevated levels of petite formation in strains of Saccharomyces cerevisiae restored to respiratory competence. II. Organization of mitochondrial genomes in strains having high and moderate frequencies of petite mutant formation.

2. Contingency and selection in mitochondrial genome dynamics.

3. Sequence rearrangements at the ori 7 region of Saccharomyces cerevisiae mitochondrial DNA.

4. Preferential recombination between GC clusters in yeast mitochondrial DNA.