Literature DB >> 6329085

Phosphorylation of four acyclic guanosine analogs by herpes simplex virus type 2 thymidine kinase.

A Larsson, P Z Tao.   

Abstract

Four acyclic guanosine analogs, the (R) and (S) enantiomers of 9-(3,4-dihydroxybutyl)guanine, 9-(4-hydroxybutyl)guanine, and acyclovir were compared in enzyme kinetic experiments, using purified herpes simplex virus type 2 thymidine kinase. All four analogs showed competitive patterns of inhibition in the phosphorylation of thymidine by the viral thymidine kinase, but different affinities and relative rates of phosphorylation were observed.

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Year:  1984        PMID： 6329085      PMCID： PMC185571          DOI： 10.1128/AAC.25.4.524

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  11 in total

1.  Thymidine kinase from herpes simplex virus phosphorylates the new antiviral compound, 9-(2-hydroxyethoxymethyl)guanine.

Authors:  J A Fyfe; P M Keller; P A Furman; R L Miller; G B Elion
Journal:  J Biol Chem       Date:  1978-12-25       Impact factor: 5.157

2.  An assay for pyrimidine deoxyribonucleoside kinase using gamma-32P-labeled ATP.

Authors:  M J Dobersen; S Greer
Journal:  Anal Biochem       Date:  1975-08       Impact factor: 3.365

3.  Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl) guanine.

Authors:  G B Elion; P A Furman; J A Fyfe; P de Miranda; L Beauchamp; H J Schaeffer
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

4.  Enzymatic phosphorylation of acyclic nucleoside analogs and correlations with antiherpetic activities.

Authors:  P M Keller; J A Fyfe; L Beauchamp; C M Lubbers; P A Furman; H J Schaeffer; G B Elion
Journal:  Biochem Pharmacol       Date:  1981-11-15       Impact factor: 5.858

Review 5.  Antiviral and antitumor activities of 5-substituted 2'-deoxyuridines.

Authors:  E De Clercq
Journal:  Methods Find Exp Clin Pharmacol       Date:  1980-10

6.  Deoxythymidine kinase induced in HeLa TK- cells by herpes simplex virus type I and type II. II. Purification and characterization.

Authors:  Y C Cheng; M Ostrander
Journal:  J Biol Chem       Date:  1976-05-10       Impact factor: 5.157

7.  Properties of purified enzymes induced by pathogenic drug-resistant mutants of herpes simplex virus. Evidence for virus variants expressing normal DNA polymerase and altered thymidine kinase.

Authors:  B A Larder; D Derse; Y C Cheng; G Darby
Journal:  J Biol Chem       Date:  1983-02-10       Impact factor: 5.157

8.  A new nucleoside analog, 9-[[2-hydroxy-1-(hydroxymethyl)ethoxyl]methyl]guanine, highly active in vitro against herpes simplex virus types 1 and 2.

Authors:  K O Smith; K S Galloway; W L Kennell; K K Ogilvie; B K Radatus
Journal:  Antimicrob Agents Chemother       Date:  1982-07       Impact factor: 5.191

9.  Antiherpetic activity and mechanism of action of 9-(4-hydroxybutyl)guanine.

Authors:  A Larsson; S Alenius; N G Johansson; B Oberg
Journal:  Antiviral Res       Date:  1983-08       Impact factor: 5.970

10.  9-(3,4-dihydroxybutyl)guanine, a new inhibitor of herpesvirus multiplication.

Authors:  A Larsson; B Oberg; S Alenius; C E Hagberg; N G Johansson; B Lindborg; G Stening
Journal:  Antimicrob Agents Chemother       Date:  1983-05       Impact factor: 5.191
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  7 in total

1.  Acyclic guanosine analogs as substrates for varicella-zoster virus thymidine kinase.

Authors:  A R Karlström; C F Källander; G Abele; A Larsson
Journal:  Antimicrob Agents Chemother       Date:  1986-01       Impact factor: 5.191

2.  Mutation within the herpes simplex virus DNA polymerase gene conferring resistance to (R)-9-(3,4-dihydroxybutyl)guanine.

Authors:  H C Chiou; K M Kerns; D M Coen
Journal:  Antimicrob Agents Chemother       Date:  1986-09       Impact factor: 5.191

3.  Acyclic guanosine analogs as inhibitors of human cytomegalovirus.

Authors:  B Wahren; A Larsson; U Rudén; A Sundqvist; E Sølver
Journal:  Antimicrob Agents Chemother       Date:  1987-02       Impact factor: 5.191

4.  Mode of action, toxicity, pharmacokinetics, and efficacy of some new antiherpesvirus guanosine analogs related to buciclovir.

Authors:  A Larsson; K Stenberg; A C Ericson; U Haglund; W A Yisak; N G Johansson; B Oberg; R Datema
Journal:  Antimicrob Agents Chemother       Date:  1986-10       Impact factor: 5.191

5.  Efficacy of the acyclic guanosine analog buciclovir [(R)-9-(3,4-dihydroxybutyl)guanine] in experimental genital herpes.

Authors:  B Lundgren; A C Ericson; M Berg; R Datema
Journal:  Antimicrob Agents Chemother       Date:  1986-02       Impact factor: 5.191

6.  Antiherpes effects and pharmacokinetic properties of 9-(4-hydroxybutyl) guanine and the (R) and (S) enantiomers of 9-(3,4-dihydroxybutyl)guanine.

Authors:  A C Ericson; A Larsson; F Y Aoki; W A Yisak; N G Johansson; B Oberg; R Datema
Journal:  Antimicrob Agents Chemother       Date:  1985-05       Impact factor: 5.191

7.  Geldanamycin, a ligand of heat shock protein 90, inhibits the replication of herpes simplex virus type 1 in vitro.

Authors:  Yu-Huan Li; Pei-Zhen Tao; Yu-Zhen Liu; Jian-Dong Jiang
Journal:  Antimicrob Agents Chemother       Date:  2004-03       Impact factor: 5.191
  7 in total

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