Literature DB >> 6328651

Action of the e locus of mice in the response of phaeomelanic hair follicles to alpha-melanocyte-stimulating hormone in vitro.

H B Tamate, T Takeuchi.   

Abstract

Dibutyryl adenosine 3',5'-monophosphate (dibutyryl cyclic AMP) induced eumelanin synthesis in hair bulb melanocytes of recessive yellow (e/e) mice in vitro, whereas alpha-melanocyte-stimulating hormone (alpha-MSH) did not. In contrast, the melanocytes of lethal yellow (Ay/a) mice produced eumelanin in response to both dibutyryl cyclic AMP and alpha-MSH. These results suggest that the e locus controls a mechanism that determines the function of an alpha-MSH receptor.

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Year:  1984        PMID： 6328651     DOI： 10.1126/science.6328651

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  10 in total

1.  Preservation of eumelanin hair pigmentation in proopiomelanocortin-deficient mice on a nonagouti (a/a) genetic background.

Authors:  Andrzej Slominski; Przemyslaw M Plonka; Alexander Pisarchik; James L Smart; Virginie Tolle; Jacobo Wortsman; Malcolm J Low
Journal:  Endocrinology       Date:  2004-11-24       Impact factor: 4.736

Review 2.  MC1R, the cAMP pathway, and the response to solar UV: extending the horizon beyond pigmentation.

Authors:  Jose C García-Borrón; Zalfa Abdel-Malek; Celia Jiménez-Cervantes
Journal:  Pigment Cell Melanoma Res       Date:  2014-05-30       Impact factor: 4.693

3.  Ectopic expression of the agouti gene in transgenic mice causes obesity, features of type II diabetes, and yellow fur.

Authors:  M L Klebig; J E Wilkinson; J G Geisler; R P Woychik
Journal:  Proc Natl Acad Sci U S A       Date:  1995-05-23       Impact factor: 11.205

4.  Synthesis and characterization of a melanoma-targeted fluorescence imaging probe by conjugation of a melanocortin 1 receptor (MC1R) specific ligand.

Authors:  Narges K Tafreshi; Xuan Huang; Valerie E Moberg; Natalie M Barkey; Vernon K Sondak; Haibin Tian; David L Morse; Josef Vagner
Journal:  Bioconjug Chem       Date:  2012-11-27       Impact factor: 4.774

5.  Development of hMC1R Selective Small Agonists for Sunless Tanning and Prevention of Genotoxicity of UV in Melanocytes.

Authors:  Leonid Koikov; Renny J Starner; Viki B Swope; Parth Upadhyay; Yuki Hashimoto; Katie T Freeman; James J Knittel; Carrie Haskell-Luevano; Zalfa A Abdel-Malek
Journal:  J Invest Dermatol       Date:  2021-02-18       Impact factor: 8.551

Review 6.  Melanocortin 1 Receptor: Structure, Function, and Regulation.

Authors:  Erin M Wolf Horrell; Mary C Boulanger; John A D'Orazio
Journal:  Front Genet       Date:  2016-05-31       Impact factor: 4.599

Review 7.  Significance of the Melanocortin 1 and Endothelin B Receptors in Melanocyte Homeostasis and Prevention of Sun-Induced Genotoxicity.

Authors:  Viki B Swope; Zalfa A Abdel-Malek
Journal:  Front Genet       Date:  2016-08-17       Impact factor: 4.599

Review 8.  Targeting GPCRs and Their Signaling as a Therapeutic Option in Melanoma.

Authors:  Jérémy H Raymond; Zackie Aktary; Lionel Larue; Véronique Delmas
Journal:  Cancers (Basel)       Date:  2022-01-29       Impact factor: 6.639

9.  Defining MC1R regulation in human melanocytes by its agonist α-melanocortin and antagonists agouti signaling protein and β-defensin 3.

Authors:  Viki B Swope; Joshua A Jameson; Kevin L McFarland; Dorothy M Supp; William E Miller; Dennis W McGraw; Mira A Patel; Matthew A Nix; Glenn L Millhauser; George F Babcock; Zalfa A Abdel-Malek
Journal:  J Invest Dermatol       Date:  2012-05-10       Impact factor: 8.551

Review 10.  MC1R: Front and Center in the Bright Side of Dark Eumelanin and DNA Repair.

Authors:  Viki B Swope; Zalfa A Abdel-Malek
Journal:  Int J Mol Sci       Date:  2018-09-08       Impact factor: 5.923
  10 in total

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