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Literature DB >> 6328327

Reverse gyrase--a topoisomerase which introduces positive superhelical turns into DNA.

Abstract

An enzymatic activity which converts closed circular DNA into a positively supercoiled form is present in cellular extracts of Sulfolobus, an acidothermophilic archaebacterium. This novel enzyme is a type II DNA topoisomerase and is active only at temperatures greater than 55 degrees C, in the presence of ATP and Mg2+.

Entities: Chemical

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Year: 1984 PMID： 6328327 DOI： 10.1038/309677a0

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

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Cited

74 in total

1. Palindromes as substrates for multiple pathways of recombination in Escherichia coli.

Authors: G A Cromie; C B Millar; K H Schmidt; D R Leach
Journal: Genetics Date: 2000-02 Impact factor: 4.562

2. Speculations on the origin of life and thermophily: review of available information on reverse gyrase suggests that hyperthermophilic procaryotes are not so primitive.

Authors: P Forterre; F Confalonieri; F Charbonnier; M Duguet
Journal: Orig Life Evol Biosph Date: 1995-06 Impact factor: 1.950

Reverse gyrase--a topoisomerase which introduces positive superhelical turns into DNA.

1. Palindromes as substrates for multiple pathways of recombination in Escherichia coli.

2. Speculations on the origin of life and thermophily: review of available information on reverse gyrase suggests that hyperthermophilic procaryotes are not so primitive.

3. Crystal structure of reverse gyrase: insights into the positive supercoiling of DNA.

4. A type IB topoisomerase with DNA repair activities.

5. Evidence that a plasmid from a hyperthermophilic archaebacterium is relaxed at physiological temperatures.

6. Reverse gyrase has heat-protective DNA chaperone activity independent of supercoiling.

7. Reverse gyrase is not a prerequisite for hyperthermophilic life.

8. Separate and combined biochemical activities of the subunits of a naturally split reverse gyrase.

9. Phenotypic characterization of the archaebacterial genus Sulfolobus: comparison of five wild-type strains.

10. Chromosome map of the thermophilic archaebacterium Thermococcus celer.