Literature DB >> 6328283

Toxicity of 2-deoxygalactose to Saccharomyces cerevisiae cells constitutively synthesizing galactose-metabolizing enzymes.

T Platt.   

Abstract

Analysis of 400 independent spontaneous mutations conferring 2-deoxygalactose resistance upon cells constitutive for the galactose pathway suggests that toxicity is due to 2-deoxygalactose-1-phosphate. Selection for and against growth on galactose in the same strain is now possible; application to systems with transcriptional or translational gene fusions to galactokinase are discussed.

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Year:  1984        PMID： 6328283      PMCID： PMC368858          DOI： 10.1128/mcb.4.5.994-996.1984

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  27 in total

1.  Genetic control of galactokinase synthesis in Saccharomyces cerevisiae: evidence for constitutive expression of the positive regulatory gene gal4.

Authors:  K Matsumoto; A Toh-e; Y Oshima
Journal:  J Bacteriol       Date:  1978-05       Impact factor: 3.490

2.  Galactose transport in Saccharomyces cerevisiae. I. Nonmetabolized sugars as substrates and inducers of the galactose transport system.

Authors:  V P Cirillo
Journal:  J Bacteriol       Date:  1968-05       Impact factor: 3.490

3.  Positive selection of mutants with deletions of the gal-chl region of the Salmonella chromosome as a screening procedure for mutagens that cause deletions.

Authors:  M D Alper; B N Ames
Journal:  J Bacteriol       Date:  1975-01       Impact factor: 3.490

4.  Deletion analysis of the Saccharomyces GAL gene cluster. Transcription from three promoters.

Authors:  T P St John; S Scherer; M W McDonell; R W Davis
Journal:  J Mol Biol       Date:  1981-10-25       Impact factor: 5.469

5.  Genetic mapping in Saccharomyces.

Authors:  R K Mortimer; D C Hawthorne
Journal:  Genetics       Date:  1966-01       Impact factor: 4.562

6.  Interaction of super-repressible and dominant constitutive mutations for the synthesis of galactose pathway enzymes in Saccharomyces cerevisiae.

Authors:  Y Nogi; K Matsumoto; A Toh-e; Y Oshima
Journal:  Mol Gen Genet       Date:  1977-04-29

7.  Isolation of galactose-inducible DNA sequences from Saccharomyces cerevisiae by differential plaque filter hybridization.

Authors:  T P St John; R W Davis
Journal:  Cell       Date:  1979-02       Impact factor: 41.582

8.  Uninducible mutants in the gal i locus of Saccharomyces cerevisiae.

Authors:  H C Douglas; C D Hawthorne
Journal:  J Bacteriol       Date:  1972-03       Impact factor: 3.490

9.  Isolation and characterization of dominant mutations resistant to carbon catabolite repression of galactokinase synthesis in Saccharomyces cerevisiae.

Authors:  K Matsumoto; A Toh-e; Y Oshima
Journal:  Mol Cell Biol       Date:  1981-02       Impact factor: 4.272

10.  The expression in yeast of the Escherichia coli galK gene on CYC1::galK fusion plasmids.

Authors:  B C Rymond; R S Zitomer; D Schümperli; M Rosenberg
Journal:  Gene       Date:  1983-11       Impact factor: 3.688
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  21 in total

1.  Parasexuality and ploidy change in Candida tropicalis.

Authors:  Riyad N H Seervai; Stephen K Jones; Matthew P Hirakawa; Allison M Porman; Richard J Bennett
Journal:  Eukaryot Cell       Date:  2013-10-11

2.  Genetic analysis of transcription-associated mutation in Saccharomyces cerevisiae.

Authors:  N J Morey; C N Greene; S Jinks-Robertson
Journal:  Genetics       Date:  2000-01       Impact factor: 4.562

3.  Direct selection for sequences encoding proteases of known specificity.

Authors:  T A Smith; B D Kohorn
Journal:  Proc Natl Acad Sci U S A       Date:  1991-06-15       Impact factor: 11.205

4.  Genetic and molecular characterization of GAL83: its interaction and similarities with other genes involved in glucose repression in Saccharomyces cerevisiae.

Authors:  J R Erickson; M Johnston
Journal:  Genetics       Date:  1993-11       Impact factor: 4.562

5.  Selection systems based on dominant-negative transcription factors for precise genetic engineering.

Authors:  Raphaël Dutoit; Evelyne Dubois; Eric Jacobs
Journal:  Nucleic Acids Res       Date:  2010-08-11       Impact factor: 16.971

6.  Mutations that inactivate a yeast transcriptional regulatory protein cluster in an evolutionarily conserved DNA binding domain.

Authors:  M Johnston; J Dover
Journal:  Proc Natl Acad Sci U S A       Date:  1987-04       Impact factor: 11.205

7.  SIP1 is a catabolite repression-specific negative regulator of GAL gene expression.

Authors:  L M Mylin; V L Bushman; R M Long; X Yu; C M Lebo; T E Blank; J E Hopper
Journal:  Genetics       Date:  1994-07       Impact factor: 4.562

8.  Transcription of multiple copies of the yeast GAL7 gene is limited by specific factors in addition to GAL4.

Authors:  S M Baker; S A Johnston; J E Hopper; J A Jaehning
Journal:  Mol Gen Genet       Date:  1987-06

9.  Completion of a parasexual cycle in Candida albicans by induced chromosome loss in tetraploid strains.

Authors:  Richard J Bennett; Alexander D Johnson
Journal:  EMBO J       Date:  2003-05-15       Impact factor: 11.598

10.  Structural basis for dimerization in DNA recognition by Gal4.

Authors:  Manqing Hong; Mary X Fitzgerald; Sandy Harper; Cheng Luo; David W Speicher; Ronen Marmorstein
Journal:  Structure       Date:  2008-07       Impact factor: 5.006
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