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Literature DB >> 6328280

Tyrosyl and cyclic AMP-dependent protein kinase activities in BHK cells that express viral pp60src.

Abstract

Protein kinase activities were measured in Rous sarcoma virus-infected baby hamster kidney (BHK) cells that express v-src (BHK [v-src]) and compared with those of revertant and control BHK cells. We observed about a fivefold-higher tyrosine phosphorylating activity in BHK (v-src) cell extracts, which was due to src but not other cellular tyrosyl kinase activities since preincubation with anti-src serum reduced the activity to control cell levels. The cyclic AMP-dependent protein kinase activity was also altered when v-src was expressed. Resolution of the two cyclic AMP-dependent isozymes from the detergent-soluble fraction of cells revealed that the type I activity was selectively decreased about fivefold in BHK (v-src) cells.

Entities: Chemical Disease Gene

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Year: 1984 PMID： 6328280 PMCID： PMC368851 DOI： 10.1128/mcb.4.5.973-977.1984

Source DB: PubMed Journal: Mol Cell Biol ISSN： 0270-7306 Impact factor: 4.272

19 in total

1. Cytoskeletal elements of chick embryo fibroblasts revealed by detergent extraction.

Authors: S Brown; W Levinson; J A Spudich
Journal: J Supramol Struct Date: 1976

2. Cell cycle-specific activity of type I and type II cyclic adenosine 3':5'-monophosphate-dependent protein kinases in Chinese hamster ovary cells.

Authors: M Costa; E W Gerner; D H Russell
Journal: J Biol Chem Date: 1976-06-10 Impact factor: 5.157

3. The distribution and dissociation of cyclic adenosine 3':5'-monophosphate-dependent protein kinases in adipose, cardiac, and other tissues.

Authors: J D Corbin; S L Keely; C R Park
Journal: J Biol Chem Date: 1975-01-10 Impact factor: 5.157

9. Independent expression of cardiac type I and II cyclic AMP-dependent protein kinase during murine embryogenesis and postnatal development.

Authors: M K Haddox; W R Roeske; D H Russell
Journal: Biochim Biophys Acta Date: 1979-07-18

Tyrosyl and cyclic AMP-dependent protein kinase activities in BHK cells that express viral pp60src.

1. Cytoskeletal elements of chick embryo fibroblasts revealed by detergent extraction.

2. Cell cycle-specific activity of type I and type II cyclic adenosine 3':5'-monophosphate-dependent protein kinases in Chinese hamster ovary cells.

3. The distribution and dissociation of cyclic adenosine 3':5'-monophosphate-dependent protein kinases in adipose, cardiac, and other tissues.

4. Type I and type II cyclic AMP-dependent protein kinase as opposite effectors of lymphocyte mitogenesis.

5. Rise and fall of cyclic AMP required for onset of lymphocyte DNA synthesis.

6. Characteristics of virus-specific RNA in avian sarcoma virus-transformed BHK-21 cells and revertants.

Review 7. Phosphorylation-dephosphorylation of enzymes.

8. Structural analysis of the avian sarcoma virus transforming protein: sites of phosphorylation.

9. Independent expression of cardiac type I and II cyclic AMP-dependent protein kinase during murine embryogenesis and postnatal development.

10. Four different classes of retroviruses induce phosphorylation of tyrosines present in similar cellular proteins.

1. Phosphatidylinositol kinase activity in virus-transformed and nontransformed cells.

2. Low level of cellular protein phosphorylation by nontransforming overproduced p60c-src.

3. Tyrosyl kinases acquired from anchorage-independent cells by a membrane-enveloped virus.