Literature DB >> 632825

Electroencephalography and phenytoin toxicity in mentally retarded epileptic patients.

M Iivanainen, M Viukari, A M Seppäläinen, E P Helle.   

Abstract

There were significantly more diffuse and focal electroencephalographic abnormalities in 127 mentally retarded epileptic patients treated with phenytoin than in 68 epileptics without phenytoin. Phenytoin intoxication made the difference still more pronounced. Monitoring drug levels and electroencephalograms appears to be the method of choice for ensuring safe and effective medication in intractable epilepsy.

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Year:  1978        PMID： 632825      PMCID： PMC493006          DOI： 10.1136/jnnp.41.3.272

Source DB:  PubMed          Journal:  J Neurol Neurosurg Psychiatry        ISSN： 0022-3050            Impact factor:   10.154


  19 in total

1.  SERUM PHENYTOIN DETERMINATIONS IN EPILEPTICS.

Authors:  P A STENSRUD; H PALMER
Journal:  Epilepsia       Date:  1964-12       Impact factor: 5.864

2.  DIPHENYLHYDANTOIN ACTIVATED SEIZURES.

Authors:  L L LEVY; G M FENICHEL
Journal:  Neurology       Date:  1965-08       Impact factor: 9.910

3.  Dilantin toxicity. A clinical and electroence-phalographic study.

Authors:  E ROSEMAN
Journal:  Neurology       Date:  1961-10       Impact factor: 9.910

4.  Effect of drugs on discharge characteristics of chronic epileptogenic lesions.

Authors:  F MORRELL; W BRADLEY; M PTASHNE
Journal:  Neurology       Date:  1959-07       Impact factor: 9.910

5.  Clinical and electroencephalographic correlations with serum levels of diphenylhydanotin.

Authors:  F BUCHTHAL; O SVENSMARK; P J SCHILLER
Journal:  Arch Neurol       Date:  1960-06

6.  Cerebellar atrophy in phenytoin-treated mentally retarded epileptics.

Authors:  M Iivanainen; M Viukari; E P Helle
Journal:  Epilepsia       Date:  1977-09       Impact factor: 5.864

7.  Serum-phenytoin, seizures, and electroencephalography.

Authors:  M Iivanainen; M Viukari
Journal:  Lancet       Date:  1977-04-16       Impact factor: 79.321

8.  Acute conduction velocity changes in guinea-pigs after administration of diphenylhydantoin.

Authors:  P M Le Quesne; V Goldberg; F Vajda
Journal:  J Neurol Neurosurg Psychiatry       Date:  1976-10       Impact factor: 10.154

9.  Diagnostic and therapeutic reevaluation of patients with intractable epilepsy.

Authors:  R J Porter; J K Penry; J R Lacy
Journal:  Neurology       Date:  1977-11       Impact factor: 9.910

10.  Therapeutic and pharmacokinetic effects of increasing phenytoin in chronic epileptics on multiple drug therapy.

Authors:  D G Lambie; R H Johnson; R N Nanda; R A Shakir
Journal:  Lancet       Date:  1976-08-21       Impact factor: 79.321
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  1 in total

1.  Clinical and experimental studies of phenytoin-induced hyperkinesias.

Authors:  P A Nausieda; W C Koller; W J Weiner; H L Klawans
Journal:  J Neural Transm       Date:  1979       Impact factor: 3.575
  1 in total

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