Literature DB >> 6327885

Determination of the sequence alteration in the DNA of the herpes simplex virus type 1 temperature-sensitive mutant ts K.

M J Davison, V G Preston, D J McGeoch.   

Abstract

The alteration in the DNA sequence responsible for the mutant phenotype of the herpes simplex virus type 1 temperature-sensitive mutant ts K has been determined. A single C:G base pair present in the wild-type Vmw 175 immediate-early polypeptide-coding sequence has been replaced by T:A in the mutant gene. This results in the substitution of an alanine by a valine codon. In two revertants the mutant T:A base pair has been resubstituted by C:G.

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Year:  1984        PMID： 6327885     DOI： 10.1099/0022-1317-65-5-859

Source DB:  PubMed          Journal:  J Gen Virol        ISSN： 0022-1317            Impact factor:   3.891


  29 in total

1.  Herpes simplex virus IE63 acts at the posttranscriptional level to stimulate viral mRNA 3' processing.

Authors:  J McLauchlan; A Phelan; C Loney; R M Sandri-Goldin; J B Clements
Journal:  J Virol       Date:  1992-12       Impact factor: 5.103

2.  Repression of gene expression upon infection of cells with herpes simplex virus type 1 mutants impaired for immediate-early protein synthesis.

Authors:  C M Preston; M J Nicholl
Journal:  J Virol       Date:  1997-10       Impact factor: 5.103

3.  A second-site revertant of a defective herpes simplex virus ICP4 protein with restored regulatory activities and impaired DNA-binding properties.

Authors:  A A Shepard; N A DeLuca
Journal:  J Virol       Date:  1991-02       Impact factor: 5.103

4.  Herpes simplex virus immediate-early proteins ICP0 and ICP4 activate the endogenous human alpha-globin gene in nonerythroid cells.

Authors:  P Cheung; B Panning; J R Smiley
Journal:  J Virol       Date:  1997-03       Impact factor: 5.103

5.  An efficient deletion mutant packaging system for defective herpes simplex virus vectors: potential applications to human gene therapy and neuronal physiology.

Authors:  A I Geller; K Keyomarsi; J Bryan; A B Pardee
Journal:  Proc Natl Acad Sci U S A       Date:  1990-11       Impact factor: 11.205

6.  Codons 262 to 490 from the herpes simplex virus ICP4 gene are sufficient to encode a sequence-specific DNA binding protein.

Authors:  C L Wu; K W Wilcox
Journal:  Nucleic Acids Res       Date:  1990-02-11       Impact factor: 16.971

7.  Isolation of herpes simplex virus regulatory protein ICP4 as a homodimeric complex.

Authors:  D W Metzler; K W Wilcox
Journal:  J Virol       Date:  1985-08       Impact factor: 5.103

8.  Complete DNA sequence of the short repeat region in the genome of herpes simplex virus type 1.

Authors:  D J McGeoch; A Dolan; S Donald; D H Brauer
Journal:  Nucleic Acids Res       Date:  1986-02-25       Impact factor: 16.971

9.  Characterization of a herpes simplex virus regulatory protein: aggregation and phosphorylation of a temperature-sensitive variant of ICP 4.

Authors:  S W Faber; K W Wilcox
Journal:  Arch Virol       Date:  1986       Impact factor: 2.574

10.  Nucleotide sequence of the pseudorabies virus immediate early gene, encoding a strong transactivator protein.

Authors:  C Vlcek; V Paces; M Schwyzer
Journal:  Virus Genes       Date:  1989-08       Impact factor: 2.332
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