Literature DB >> 6327260

The immediate-early mRNA that encodes the regulatory polypeptide Vmw 175 of herpes simplex virus type 1 is unspliced.

F J Rixon, M E Campbell, J B Clements.   

Abstract

The structure and precise map location of the 4.1-kb herpes simplex virus type 1 (HSV-1) immediate-early mRNA (IE mRNA-3) that encodes a regulatory polypeptide, with an approximate mol. wt. of 175 000, has been determined. Nuclease S1 digestion procedures using labelled virus DNA probes have shown that IE mRNA-3 is unspliced and maps entirely within the TRs/IRs genome regions. DNA sequences at the 5' and 3' ends of IE mRNA-3 have been examined and regulatory signals involved in initiation of transcription and polyadenylation have been identified. No other mRNA is known to map within the region coding for IE mRNA-3.

Entities:  

Mesh：

Substances：

Year:  1982        PMID： 6327260      PMCID： PMC553200          DOI： 10.1002/j.1460-2075.1982.tb00024.x

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  35 in total

1.  Orientation of herpes simplex virus type 1 immediate early mRNA's.

Authors:  J B Clements; J McLauchlan; D J McGeoch
Journal:  Nucleic Acids Res       Date:  1979-09-11       Impact factor: 16.971

2.  Regulation of herpesvirus macromolecular synthesis. VIII. The transcription program consists of three phases during which both extent of transcription and accumulation of RNA in the cytoplasm are regulated.

Authors:  P C Jones; B Roizman
Journal:  J Virol       Date:  1979-08       Impact factor: 5.103

3.  Characterization of transcription-deficient temperature-sensitive mutants of herpes simplex virus type 1.

Authors:  R J Watson; J B Clements
Journal:  Virology       Date:  1978-12       Impact factor: 3.616

4.  Temporal regulation of herpes simplex virus type 1 transcription: location of transcripts on the viral genome.

Authors:  J B Clements; R J Watson; N M Wilkie
Journal:  Cell       Date:  1977-09       Impact factor: 41.582

5.  Control of herpes simplex virus type 1 mRNA synthesis in cells infected with wild-type virus or the temperature-sensitive mutant tsK.

Authors:  C M Preston
Journal:  J Virol       Date:  1979-01       Impact factor: 5.103

6.  Organisation and sequences at the 5' end of a cloned complete ovalbumin gene.

Authors:  F Gannon; K O'Hare; F Perrin; J P LePennec; C Benoist; M Cochet; R Breathnach; A Royal; A Garapin; B Cami; P Chambon
Journal:  Nature       Date:  1979-03-29       Impact factor: 49.962

7.  Transcription maps of polyoma virus-specific RNA: analysis by two-dimensional nuclease S1 gel mapping.

Authors:  J Favaloro; R Treisman; R Kamen
Journal:  Methods Enzymol       Date:  1980       Impact factor: 1.600

8.  3' non-coding region sequences in eukaryotic messenger RNA.

Authors:  N J Proudfoot; G G Brownlee
Journal:  Nature       Date:  1976-09-16       Impact factor: 49.962

9.  Sequencing end-labeled DNA with base-specific chemical cleavages.

Authors:  A M Maxam; W Gilbert
Journal:  Methods Enzymol       Date:  1980       Impact factor: 1.600

10.  Characterization of herpes simplex virus type 1 RNA present in the absence of de novo protein synthesis.

Authors:  K P Anderson; R H Costa; L E Holland; E K Wagner
Journal:  J Virol       Date:  1980-04       Impact factor: 5.103
View more
  11 in total

1.  Stimulation of expression of a herpes simplex virus DNA-binding protein by two viral functions.

Authors:  M P Quinlan; D M Knipe
Journal:  Mol Cell Biol       Date:  1985-05       Impact factor: 4.272

2.  Complete DNA sequence of the short repeat region in the genome of herpes simplex virus type 1.

Authors:  D J McGeoch; A Dolan; S Donald; D H Brauer
Journal:  Nucleic Acids Res       Date:  1986-02-25       Impact factor: 16.971

3.  Quantification of transcripts from the ICP4 and thymidine kinase genes in mouse ganglia latently infected with herpes simplex virus.

Authors:  M F Kramer; D M Coen
Journal:  J Virol       Date:  1995-03       Impact factor: 5.103

4.  Analysis of DNA sequences which regulate the transcription of a herpes simplex virus immediate early gene.

Authors:  C M Preston; M G Cordingley; N D Stow
Journal:  J Virol       Date:  1984-06       Impact factor: 5.103

5.  A 3' co-terminal family of mRNAs from the herpes simplex virus type 1 short region: two overlapping reading frames encode unrelated polypeptide one of which has highly reiterated amino acid sequence.

Authors:  F J Rixon; D J McGeoch
Journal:  Nucleic Acids Res       Date:  1984-03-12       Impact factor: 16.971

6.  Functional analysis of a herpes simplex virus type 1 promoter: identification of far-upstream regulatory sequences.

Authors:  M G Cordingley; M E Campbell; C M Preston
Journal:  Nucleic Acids Res       Date:  1983-04-25       Impact factor: 16.971

7.  Sequences of herpes simplex virus type 1 that inhibit formation of stable TK+ transformants.

Authors:  D H Farkas; T M Block; P B Hart; R G Hughes
Journal:  J Virol       Date:  1987-10       Impact factor: 5.103

8.  The immediate-early enhancer element of herpes simplex virus type 1 can replace a regulatory region of the c-Ha-ras1 oncogene required for transformation.

Authors:  A Puga; J Gomez-Marquez; P R Brayton; E M Cantin; L K Long; M Barbacid; A L Notkins
Journal:  J Virol       Date:  1985-06       Impact factor: 5.103

9.  The consensus sequence YGTGTTYY located downstream from the AATAAA signal is required for efficient formation of mRNA 3' termini.

Authors:  J McLauchlan; D Gaffney; J L Whitton; J B Clements
Journal:  Nucleic Acids Res       Date:  1985-02-25       Impact factor: 16.971

10.  The regions of the herpes simplex virus type 1 immediate early protein Vmw175 required for site specific DNA binding closely correspond to those involved in transcriptional regulation.

Authors:  T Paterson; R D Everett
Journal:  Nucleic Acids Res       Date:  1988-12-09       Impact factor: 16.971
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.