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Literature DB >> 6327052

Gene amplification in the lac region of E. coli.

Abstract

We have characterized strains of E. coli in which the lac region, together with varying amounts of surrounding DNA, is amplified 40 to 200 fold. The amplification events involve regions of 7 to 37 kb and result in a tandem array of repeated units. Restriction digest patterns of DNA from over 100 independent strains reveal that the amplified units are different in each case. Mechanisms of gene duplication and amplification, and the relationship of gene amplification in bacteria to that in eucaryotic cells, are considered.

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Year: 1984 PMID： 6327052 DOI： 10.1016/0092-8674(84)90317-9

Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582

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Cited

73 in total

Review 1. Mechanisms of stationary phase mutation: a decade of adaptive mutation.

Authors: P L Foster
Journal: Annu Rev Genet Date: 1999 Impact factor: 16.830

2. How long did it take for life to begin and evolve to cyanobacteria?

Authors: A Lazcano; S L Miller
Journal: J Mol Evol Date: 1994-12 Impact factor: 2.395

3. Increased episomal replication accounts for the high rate of adaptive mutation in recD mutants of Escherichia coli.

Authors: P L Foster; W A Rosche
Journal: Genetics Date: 1999-05 Impact factor: 4.562

4. Adaptive mutation: general mutagenesis is not a programmed response to stress but results from rare coamplification of dinB with lac.

Authors: E Susan Slechta; Kim L Bunny; Elisabeth Kugelberg; Eric Kofoid; Dan I Andersson; John R Roth
Journal: Proc Natl Acad Sci U S A Date: 2003-10-14 Impact factor: 11.205

5. Adaptive point mutation and adaptive amplification pathways in the Escherichia coli Lac system: stress responses producing genetic change.

Authors: Susan M Rosenberg; P J Hastings
Journal: J Bacteriol Date: 2004-08 Impact factor: 3.490

Gene amplification in the lac region of E. coli.

Review 1. Mechanisms of stationary phase mutation: a decade of adaptive mutation.

2. How long did it take for life to begin and evolve to cyanobacteria?

3. Increased episomal replication accounts for the high rate of adaptive mutation in recD mutants of Escherichia coli.

4. Adaptive mutation: general mutagenesis is not a programmed response to stress but results from rare coamplification of dinB with lac.

5. Adaptive point mutation and adaptive amplification pathways in the Escherichia coli Lac system: stress responses producing genetic change.

6. Adaptive mutation in Escherichia coli.

7. Adaptive mutation: how growth under selection stimulates Lac(+) reversion by increasing target copy number.

8. General stress response regulator RpoS in adaptive mutation and amplification in Escherichia coli.

Review 9. Directed mutation: between unicorns and goats.

10. Stress-Induced Mutagenesis: Implications in Cancer and Drug Resistance.