| Literature DB >> 6327049 |
H T Cuypers, G Selten, W Quint, M Zijlstra, E R Maandag, W Boelens, P van Wezenbeek, C Melief, A Berns.
Abstract
A number of mink cell focus-forming (MCF) proviruses was molecularly cloned from mouse lymphoma DNA. From each clone, flanking probes were prepared to detect common integration regions in other MuLV-induced lymphomas. One clone frequently revealed variations in the molecular structure of the corresponding region (Pim-1) in other lymphomas. The results show the following. Changes in the Pim region are seen in 24 out of 93 lymphomas tested. Over 50% of the early T-cell lymphomas show integration in the Pim-1 region. The alterations are seen in different mouse strains and with various MuLVs. The observed variations are caused by the integration of predominantly MCF genomes. All integrations occur in a region spanning less than 20 kb and are associated with the transcriptional activation of a distinct region within the Pim-1 domain. The activated region does not show any homology with 13 known and three putative oncogenes.Entities:
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Year: 1984 PMID： 6327049 DOI： 10.1016/0092-8674(84)90309-x
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582