Literature DB >> 6326901

Age-related decline of human interferon alpha and interferon gamma production.

J Abb, H Abb, F Deinhardt.   

Abstract

The influence of donor age on the production of interferon (IFN) alpha and IFN gamma by human peripheral blood mononuclear cells in vitro has been studied. The results demonstrate an age-related decline of the capacity to synthesize and secrete antiviral activity. Yields of virus-induced IFN alpha and lectin-induced IFN gamma were significantly decreased in mononuclear cell cultures from older subjects (greater than 50 years) when compared to those of younger subjects (less than 50 years). The observed deficiency of IFN production may be involved in the increased susceptibility of aged humans to viral infections and malignant diseases.

Entities:  

Mesh：

Substances：

Year:  1984        PMID： 6326901     DOI： 10.1007/bf00320399

Source DB:  PubMed          Journal:  Blut        ISSN： 0006-5242


  9 in total

Review 1.  Mechanisms of activation of human natural killer cells against tumor and virus-infected cells.

Authors:  D Santoli; H Koprowski
Journal:  Immunol Rev       Date:  1979       Impact factor: 12.988

2.  Augmentation by interferon of human natural and antibody-dependent cell-mediated cytotoxicity.

Authors:  R R Herberman; J R Ortaldo; G D Bonnard
Journal:  Nature       Date:  1979-01-18       Impact factor: 49.962

3.  Effect of age upon primary alloantigen recognition by mouse spleen cells.

Authors:  W H Adler; T Takiguchi; R T Smith
Journal:  J Immunol       Date:  1971-11       Impact factor: 5.422

4.  Change of cell-mediated cytotoxicity with aging.

Authors:  S Shigemoto; S Kishimoto; Y Yamamura
Journal:  J Immunol       Date:  1975-07       Impact factor: 5.422

5.  Effects of aging on the differentiation and proliferation potentials of cells of the immune system.

Authors:  T Makinodan; W H Adler
Journal:  Fed Proc       Date:  1975-02

6.  Phenotype of human alpha-interferon producing leucocytes identified by monoclonal antibodies.

Authors:  J Abb; H Abb; F Deinhardt
Journal:  Clin Exp Immunol       Date:  1983-04       Impact factor: 4.330

7.  Immunologic studies of aging. V. Impaired proliferation of PHA responsive human lymphocytes in culture.

Authors:  J M Hefton; G J Darlington; B A Casazza; M E Weksler
Journal:  J Immunol       Date:  1980-09       Impact factor: 5.422

8.  Characterization of human interferon-gamma-producing leukocytes with monoclonal antileukocyte antibodies.

Authors:  J Abb; H Abb; F Deinhardt
Journal:  Med Microbiol Immunol       Date:  1983       Impact factor: 3.402

9.  Cytokinetic analysis of the impaired proliferative response of peripheral lymphocytes from aged humans to phytohemagglutinin.

Authors:  R R Tice; E L Schneider; D Kram; P Thorne
Journal:  J Exp Med       Date:  1979-05-01       Impact factor: 14.307
  9 in total
  20 in total

1.  Gender specificity of altered human immune cytokine profiles in aging.

Authors:  Edward J Goetzl; Mei-Chuan Huang; Junko Kon; Kalpesh Patel; Janice B Schwartz; Katharine Fast; Luigi Ferrucci; Karen Madara; Dennis D Taub; Dan L Longo
Journal:  FASEB J       Date:  2010-05-07       Impact factor: 5.191

2.  Low in vitro production of interferon-gamma and tumor necrosis factor-alpha in HIV-seronegative patients with pulmonary disease caused by nontuberculous mycobacteria.

Authors:  U Greinert; M Schlaak; S Rüsch-Gerdes; H D Flad; M Ernst
Journal:  J Clin Immunol       Date:  2000-11       Impact factor: 8.317

Review 3.  T-cell biology in aging, with a focus on lung disease.

Authors:  Naeun Lee; Min Sun Shin; Insoo Kang
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2012-03-05       Impact factor: 6.053

4.  Reversal by lymphokines of the age-related hyporesponsiveness to contact sensitization and reduced Ia expression on Langerhans cells.

Authors:  D V Belsito; R M Dersarkissian; G J Thorbecke; R L Baer
Journal:  Arch Dermatol Res       Date:  1987       Impact factor: 3.017

5.  Vitamin E supplementation increases T helper 1 cytokine production in old mice infected with influenza virus.

Authors:  S N Han; D Wu; W K Ha; A Beharka; D E Smith; B S Bender; S N Meydani
Journal:  Immunology       Date:  2000-08       Impact factor: 7.397

6.  Interferon induction in swine lymphocyte antigen-defined miniature pigs.

Authors:  L T Jordan; J B Derbyshire; B A Mallard
Journal:  Res Vet Sci       Date:  1995-05       Impact factor: 2.534

7.  Aging impairs IFN regulatory factor 7 up-regulation in plasmacytoid dendritic cells during TLR9 activation.

Authors:  Heather W Stout-Delgado; Xin Yang; Wendy E Walker; Bethany M Tesar; Daniel R Goldstein
Journal:  J Immunol       Date:  2008-11-15       Impact factor: 5.422

Review 8.  Targeted antioxidants as therapeutics for treatment of pneumonia in the elderly.

Authors:  Stefi F Lee; Rebecca Harris; Heather W Stout-Delgado
Journal:  Transl Res       Date:  2020-03-16       Impact factor: 7.012

Review 9.  Low zinc status: a new risk factor for pneumonia in the elderly?

Authors:  Junaidah B Barnett; Davidson H Hamer; Simin N Meydani
Journal:  Nutr Rev       Date:  2010-01       Impact factor: 7.110

10.  Age-associated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response.

Authors:  Alexander Panda; Feng Qian; Subhasis Mohanty; David van Duin; Frances K Newman; Lin Zhang; Shu Chen; Virginia Towle; Robert B Belshe; Erol Fikrig; Heather G Allore; Ruth R Montgomery; Albert C Shaw
Journal:  J Immunol       Date:  2010-01-25       Impact factor: 5.422
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.