Literature DB >> 6326711

Neurovirulence of an herpes simplex type 1 thymidine kinase negative mutant determined by virus biochemical defect and host immune system in mice. Brief report.

Y J Gordon, P L Simon, J A Armstrong.   

Abstract

While the biochemical defect of the thymidine kinase negative HSV-1 mutant restricts virus replication in mouse neural tissue, and thereby reduces neurovirulence, the host immune system also limits HSV-1 TK- replication in permissive glial cells in immunocompetent mice, and reduces neurovirulence.

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Year:  1984        PMID： 6326711     DOI： 10.1007/bf01310662

Source DB:  PubMed          Journal:  Arch Virol        ISSN： 0304-8608            Impact factor:   2.574


  10 in total

1.  Herpes simplex virus thymidine kinase expression in infection of the trigeminal ganglion.

Authors:  R B Tenser; M E Dunstan
Journal:  Virology       Date:  1979-12       Impact factor: 3.616

2.  Ultraviolet reactivation of herpes simplex virus is mutagenic and inducible in mammlian cells.

Authors:  U B DasGupta; W C Summers
Journal:  Proc Natl Acad Sci U S A       Date:  1978-05       Impact factor: 11.205

3.  The pathogenicity of thymidine kinase-deficient mutants of herpes simplex virus in mice.

Authors:  H J Field; P Wildy
Journal:  J Hyg (Lond)       Date:  1978-10

4.  Induction of both thymidine and deoxycytidine kinase activity by herpes viruses.

Authors:  A T Jamieson; G A Gentry; J H Subak-Sharpe
Journal:  J Gen Virol       Date:  1974-09       Impact factor: 3.891

5.  The effect of cytosine arabinoside on the replication of herpes simplex virus.

Authors:  J Levitt; Y Becker
Journal:  Virology       Date:  1967-01       Impact factor: 3.616

6.  Neurological involvement in mice after infection with a cold-adapted herpes simplex type 2 virus.

Authors:  D D Huang; G D Abrams; H F Maassab
Journal:  Infect Immun       Date:  1982-03       Impact factor: 3.441

7.  Resistance of peripheral autonomic neurons to in vivo productive infection by herpes simplex virus mutants deficient in thymidine kinase activity.

Authors:  R W Price; A Khan
Journal:  Infect Immun       Date:  1981-11       Impact factor: 3.441

8.  Atypical patterns of neural infection produced in mice by drug-resistant strains of herpes simplex virus.

Authors:  H J Field; J R Anderson; P Wildy
Journal:  J Gen Virol       Date:  1982-03       Impact factor: 3.891

9.  HSV-1 thymidine kinase promotes virulence and latency in the mouse.

Authors:  Y J Gordon; D M Gilden; Y Becker
Journal:  Invest Ophthalmol Vis Sci       Date:  1983-05       Impact factor: 4.799

10.  A low thymidine kinase-producing mutant of herpes simplex virus type 1 causes latent trigeminal ganglia infections in mice.

Authors:  Y Gordon; D H Gilden; Y Shtram; Y Asher; E Tabor; M Wellish; M Devlin; D Snipper; J Hadar; Y Becker
Journal:  Arch Virol       Date:  1983       Impact factor: 2.574
  10 in total
  2 in total

1.  Detection of latent thymidine kinase-deficient herpes simplex virus in trigeminal ganglia of mice using the polymerase chain reaction.

Authors:  A Friedrich; J P Kleim; K E Schneweis
Journal:  Arch Virol       Date:  1990       Impact factor: 2.574

2.  Amino acid differences in glycoproteins B (gB), C (gC), H (gH) and L (gL) are associated with enhanced herpes simplex virus type-1 (McKrae) entry via the paired immunoglobulin-like type-2 receptor α.

Authors:  Sona Chowdhury; Misagh Naderi; Vladimir N Chouljenko; Jason D Walker; Konstantin G Kousoulas
Journal:  Virol J       Date:  2012-06-13       Impact factor: 4.099
  2 in total

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