Literature DB >> 6326105

Evidence that the Rous sarcoma virus transforming gene product phosphorylates phosphatidylinositol and diacylglycerol.

Y Sugimoto, M Whitman, L C Cantley, R L Erikson.   

Abstract

The ability of purified Rous sarcoma virus transforming gene product, pp60v-src, to phosphorylate phosphatidylinositol and diacylglycerol was investigated. Phosphatidylinositol was phosphorylated to form both mono- and diphosphorylated derivatives. 1,2-Diacylglycerol was phosphorylated to form phosphatidic acid. These activities showed the same thermolability and the same sensitivity to inhibitors as shown by the casein kinase activity of pp60v-src. In addition, when serum-starved chicken embryo fibroblasts transformed by a virus mutant temperature-sensitive for transformation were shifted from the nonpermissive to permissive temperature, an increase of 50-100% in the labeling of phosphatidylinositol 4-phosphate, phosphatidylinositol 4,5-bisphosphate, and phosphatidic acid was observed, as compared to uninfected cells.

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Year:  1984        PMID： 6326105      PMCID： PMC345448          DOI： 10.1073/pnas.81.7.2117

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  36 in total

1.  Identification of a transformation-specific antigen induced by an avian sarcoma virus.

Authors:  J S Brugge; R L Erikson
Journal:  Nature       Date:  1977-09-22       Impact factor: 49.962

2.  Protein kinase activity associated with the avian sarcoma virus src gene product.

Authors:  M S Collett; R L Erikson
Journal:  Proc Natl Acad Sci U S A       Date:  1978-04       Impact factor: 11.205

3.  Evidence that the transforming gene of avian sarcoma virus encodes a protein kinase associated with a phosphoprotein.

Authors:  A D Levinson; H Oppermann; L Levintow; H E Varmus; J M Bishop
Journal:  Cell       Date:  1978-10       Impact factor: 41.582

4.  Immunofluorescence on avian sarcoma virus-transformed cells: localization of the src gene product.

Authors:  L R Rohrschneider
Journal:  Cell       Date:  1979-01       Impact factor: 41.582

5.  The effects of reciprocal changes in temperature on the transformed state of cells infected with a rous sarcoma virus mutant.

Authors:  S Kawai; H Hanafusa
Journal:  Virology       Date:  1971-11       Impact factor: 3.616

6.  Preparation of homogeneous cyclic AMP-dependent protein kinase(s) and its subunits from rabbit skeletal muscle.

Authors:  J A Beavo; P J Bechtel; E G Krebs
Journal:  Methods Enzymol       Date:  1974       Impact factor: 1.600

7.  Thin-layer chromatography of the phosphoinositides.

Authors:  F Gonzalez-Sastre; J Folch-Pi
Journal:  J Lipid Res       Date:  1968-07       Impact factor: 5.922

8.  Changes in phosphatidylinositol metabolism correlated to growth state of normal and Rous sarcoma virus-transformed Japanese quail cells.

Authors:  H Diringer; R R Friis
Journal:  Cancer Res       Date:  1977-09       Impact factor: 12.701

9.  Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate.

Authors:  H Streb; R F Irvine; M J Berridge; I Schulz
Journal:  Nature       Date:  1983 Nov 3-9       Impact factor: 49.962

10.  Calcium-dependent activation of a multifunctional protein kinase by membrane phospholipids.

Authors:  Y Takai; A Kishimoto; Y Iwasa; Y Kawahara; T Mori; Y Nishizuka
Journal:  J Biol Chem       Date:  1979-05-25       Impact factor: 5.157
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  115 in total

1.  SRF-dependent gene expression is required for PI3-kinase-regulated cell proliferation.

Authors:  S Poser; S Impey; K Trinh; Z Xia; D R Storm
Journal:  EMBO J       Date:  2000-09-15       Impact factor: 11.598

2.  Phosphatidylinositol kinase is activated in membranes derived from cells treated with epidermal growth factor.

Authors:  D H Walker; L J Pike
Journal:  Proc Natl Acad Sci U S A       Date:  1987-11       Impact factor: 11.205

3.  Phosphorylation and activation of epidermal growth factor receptors in cells transformed by the src oncogene.

Authors:  W J Wasilenko; D M Payne; D L Fitzgerald; M J Weber
Journal:  Mol Cell Biol       Date:  1991-01       Impact factor: 4.272

4.  Tyrosine mutations within the alpha platelet-derived growth factor receptor kinase insert domain abrogate receptor-associated phosphatidylinositol-3 kinase activity without affecting mitogenic or chemotactic signal transduction.

Authors:  J C Yu; M A Heidaran; J H Pierce; J S Gutkind; D Lombardi; M Ruggiero; S A Aaronson
Journal:  Mol Cell Biol       Date:  1991-07       Impact factor: 4.272

5.  Activation of phosphatidylinositol 3-kinase in cells expressing abl oncogene variants.

Authors:  L Varticovski; G Q Daley; P Jackson; D Baltimore; L C Cantley
Journal:  Mol Cell Biol       Date:  1991-02       Impact factor: 4.272

6.  The product of the protooncogene c-src is modified during the cellular response to platelet-derived growth factor.

Authors:  R Ralston; J M Bishop
Journal:  Proc Natl Acad Sci U S A       Date:  1985-12       Impact factor: 11.205

7.  Phosphatidylinositol kinase activity in virus-transformed and nontransformed cells.

Authors:  S Sugano; H Hanafusa
Journal:  Mol Cell Biol       Date:  1985-09       Impact factor: 4.272

8.  Association of the insulin receptor and phosphatidylinositol 3-kinase requires a third component.

Authors:  R Liu; J N Livingston
Journal:  Biochem J       Date:  1994-01-15       Impact factor: 3.857

Review 9.  PI3K signaling in glioma--animal models and therapeutic challenges.

Authors:  Christine K Cheng; Qi-Wen Fan; William A Weiss
Journal:  Brain Pathol       Date:  2009-01       Impact factor: 6.508

Review 10.  The PI3K pathway as drug target in human cancer.

Authors:  Kevin D Courtney; Ryan B Corcoran; Jeffrey A Engelman
Journal:  J Clin Oncol       Date:  2010-01-19       Impact factor: 44.544
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