Literature DB >> 632564

Immunity to challenge in volunteers vaccinated with an inactivated current or earlier strain of influenza A(H3N2).

H E Larson, D A Tyrrell, C H Bowker, C W Potter, G C Schild.   

Abstract

Volunteers were inoculated with vaccine made from the 30c mutant, A/Port Chalmers/73 or B/Hong Kong/8/73. Preliminary experiments showed that the 30 c strain was antigenically quite close to A/HK/8/68. Volunteers given 30c developed haemagglutination inhibiting antibodies against the 'current' 1973 serotypes (as well as to the vaccine virus) but the titres were less than those after the A/PC/73 vaccine. Volunteers were then challenged with a live attenuated virus, WRL 105, with A/Finland/4/74 antigens, by intranasal inoculation. The rates of infection were 43% after B/Hong Kong/8/73, 20% after 30c and 5% after A/PC/73. This indicated that the 30c gave some protection but that the vaccine prepared from the current strain gave more.

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Year:  1978        PMID: 632564      PMCID: PMC2129992          DOI: 10.1017/s0022172400053596

Source DB:  PubMed          Journal:  J Hyg (Lond)        ISSN: 0022-1724


  14 in total

1.  Influenzavirus neuraminidase and neuraminidase-inhibition test procedures.

Authors:  M Aymard-Henry; M T Coleman; W R Dowdle; W G Laver; G C Schild; R G Webster
Journal:  Bull World Health Organ       Date:  1973       Impact factor: 9.408

2.  Studies on antigenic variation in influenza virus. Evidence for multiple antigenic determinants on the hemagglutinin subunits of A-Hong Kong-68 (H3 N2) virus and the A-England-72 strains.

Authors:  W G Laver; J C Downie; R G Webster
Journal:  Virology       Date:  1974-05       Impact factor: 3.616

3.  Efficacy of "Hong Kong" vaccine in preventing "England" variant influenza A in 1972.

Authors:  H G Stiver; P Graves; T C Eickhoff; G Meiklejohn
Journal:  N Engl J Med       Date:  1973-12-13       Impact factor: 91.245

4.  Controlled trial of inactivated influenza vaccine containing the a-Hong Kong strain during an outbreak of influenza due to the a-England-42-72 strain.

Authors:  T W Hoskins; J R Davies; A Allchin; C L Miller; T M Pollock
Journal:  Lancet       Date:  1973-07-21       Impact factor: 79.321

5.  The role of serum haemagglutination-inhibiting antibody in protection against challenge infection with influenza A2 and B viruses.

Authors:  D Hobson; R L Curry; A S Beare; A Ward-Gardner
Journal:  J Hyg (Lond)       Date:  1972-12

6.  [Selection of dominant mutants of the influenza A (Hong Kong) virus by immunological pressure].

Authors:  S Fazekas de St Groth; C Hannoun
Journal:  C R Acad Hebd Seances Acad Sci D       Date:  1973-03-19

7.  Antigenic variation in current influenza A viruses: evidence for a high frequency of antigenic 'drift' for the Hong Kong virus.

Authors:  G C Schild; J S Oxford; W R Dowdle; M Coleman; M S Pereira; P Chakraverty
Journal:  Bull World Health Organ       Date:  1974       Impact factor: 9.408

8.  Isolation of anti-haemagglutinin antibodies with an influenza A virus immunoadsorbent.

Authors:  J Lecomte; D A Tyrrell
Journal:  J Immunol Methods       Date:  1976       Impact factor: 2.303

9.  Recombinant WRL 105 strain live attenuated influenza vaccine. Immunogenicity, reactivity, and transmissibility.

Authors:  C A Morris; D S Freestone; V M Stealey; P R Oliver
Journal:  Lancet       Date:  1975-08-02       Impact factor: 79.321

10.  Antibody responses to antigenic determinants of influenza virus hemagglutinin. I. Thymus dependence of antibody formation and thymus independence of immunological memory.

Authors:  J L Virelizier; R Postlethwaite; G C Schild; A C Allison
Journal:  J Exp Med       Date:  1974-12-01       Impact factor: 14.307

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  8 in total

1.  The specificity of the anti-haemagglutinin antibody response induced in man by inactivated influenza vaccines and by natural infection.

Authors:  J S Oxford; G C Schild; C W Potter; R Jennings
Journal:  J Hyg (Lond)       Date:  1979-02

2.  Evaluation of influenza virus A/H3N2 and B vaccines on the basis of cross-reactivity of postvaccination human serum antibodies against influenza viruses A/H3N2 and B isolated in MDCK cells and embryonated hen eggs.

Authors:  Noriko Kishida; Seiichiro Fujisaki; Masaru Yokoyama; Hironori Sato; Reiko Saito; Hideyuki Ikematsu; Hong Xu; Emi Takashita; Masato Tashiro; Shinichi Takao; Takuya Yano; Tomoko Suga; Chiharu Kawakami; Miwako Yamamoto; Keiko Kajiyama; Hiroyuki Saito; Shin'ichi Shimada; Sumi Watanabe; Satomi Aoki; Katsuya Taira; Miyako Kon; Jih-Hui Lin; Takato Odagiri
Journal:  Clin Vaccine Immunol       Date:  2012-04-04

3.  Projection of seasonal influenza severity from sequence and serological data.

Authors:  Yuri I Wolf; Anastasia Nikolskaya; Joshua L Cherry; Cecile Viboud; Eugene Koonin; David J Lipman
Journal:  PLoS Curr       Date:  2010-12-03

4.  Relationship between surface antigens of two variants of influenza A (H3N2) virus, as revealed by hemagglutination inhibition, kinetic neutralization, and neuraminidase inhibition.

Authors:  C N Hsia; H M Foy; M K Cooney
Journal:  Infect Immun       Date:  1980-11       Impact factor: 3.441

5.  Generation of cross-reactive cytotoxic T lymphocytes following immunization of mice with various bluetongue virus types.

Authors:  M H Jeggo; R C Wardley
Journal:  Immunology       Date:  1982-04       Impact factor: 7.397

6.  Risk factors and immunity in a nationally representative population following the 2009 influenza A(H1N1) pandemic.

Authors:  Don Bandaranayake; Q Sue Huang; Ange Bissielo; Tim Wood; Graham Mackereth; Michael G Baker; Richard Beasley; Stewart Reid; Sally Roberts; Virginia Hope
Journal:  PLoS One       Date:  2010-10-14       Impact factor: 3.240

7.  High rate of A(H1N1)pdm09 infections among rural Thai villagers, 2009-2010.

Authors:  Benjawan Khuntirat; In-Kyu Yoon; Malinee Chittaganpitch; Whitney S Krueger; Krongkaew Supawat; Patrick J Blair; Shannon D Putnam; Robert V Gibbons; Darunee Buddhari; Pathom Sawanpanyalert; Gary L Heil; John A Friary; Gregory C Gray
Journal:  PLoS One       Date:  2014-09-04       Impact factor: 3.240

Review 8.  Model answers or trivial pursuits? The role of mathematical models in influenza pandemic preparedness planning.

Authors:  J McVernon; C T McCaw; J D Mathews
Journal:  Influenza Other Respir Viruses       Date:  2007-03       Impact factor: 4.380

  8 in total

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