Literature DB >> 6325591

Differential effects of the enantiomers of 3-PPP on dopamine D1-receptors of isolated rabbit retina.

M Schorderet, S Hjorth, U Hacksell.   

Abstract

The effects of (+)- and (-)-3-PPP on cAMP levels of rabbit retina were investigated in vitro in the absence or presence of exogenous dopamine. In some experiments, a pre-incubation with reserpine was undertaken to deplete endogenous dopamine before the test. (+)- and (-)-3-PPP were found to be a weak dopamine-agonist and a weak dopamine-antagonist, respectively. Thus, the 3-PPP enantiomers may have opposite actions at the level of postsynaptic dopamine receptors, as previously suggested by studies in vivo.

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Year:  1984        PMID： 6325591     DOI： 10.1007/bf01249874

Source DB:  PubMed          Journal:  J Neural Transm            Impact factor:   3.575


  10 in total

Review 1.  Multiple receptors for dopamine.

Authors:  J W Kebabian; D B Calne
Journal:  Nature       Date:  1979-01-11       Impact factor: 49.962

2.  The isolated retina of mammals: A useful preparation for enzymatic-(adenylyl cyclase) and/or binding studies of dopamine receptors.

Authors:  M Schorderet; P J Magistretti
Journal:  Neurochem Int       Date:  1980       Impact factor: 3.921

3.  Dopaminergic mechanisms in the carp retina: Effects of dopamine, K(+) and light on cyclic AMP synthesis.

Authors:  K J Watling; J E Dowling; L L Iversen
Journal:  Neurochem Int       Date:  1980       Impact factor: 3.921

4.  A simple and sensitive saturation assay method for the measurement of adenosine 3':5'-cyclic monophosphate.

Authors:  B L Brown; J D Albano; R P Ekins; A M Sgherzi
Journal:  Biochem J       Date:  1971-02       Impact factor: 3.857

5.  3-PPP, a new centrally acting DA-receptor agonist with selectivity for autoreceptors.

Authors:  S Hjorth; A Carlsson; H Wikström; P Lindberg; D Sanchez; U Hacksell; L E Arvidsson; U Svensson; J L Nilsson
Journal:  Life Sci       Date:  1981-03-16       Impact factor: 5.037

6.  Inhibition of postsynaptic dopamine-sensitive adenylate cyclase in carp retina by the putative dopamine autoreceptor agonist, 3-PPP.

Authors:  K J Watling; J H Jones; M Williams
Journal:  Eur J Pharmacol       Date:  1982-08-13       Impact factor: 4.432

7.  Central dopamine receptor agonist and antagonist actions of the enantiomers of 3-PPP.

Authors:  S Hjorth; A Carlsson; D Clark; K Svensson; H Wikström; D Sanchez; P Lindberg; U Hacksell; L E Arvidsson; A Johansson
Journal:  Psychopharmacology (Berl)       Date:  1983       Impact factor: 4.530

8.  On the mode of action of 3-(3-hydroxyphenyl)-N-n-propylpiperidine, 3-PPP, and its enantiomers. With particular reference to dopaminergic mechanisms in the central nervous system.

Authors:  S Hjorth
Journal:  Acta Physiol Scand Suppl       Date:  1983

9.  Interaction of the putative dopamine autoreceptor agonists, 3-PPP and TL-99, with the dopamine-sensitive adenylate cyclase of carp retina.

Authors:  K J Watling; M Williams
Journal:  Eur J Pharmacol       Date:  1982-02-05       Impact factor: 4.432

10.  3-PPP antagonizes the in vitro effects of D-1 and D-2 dopamine receptor agonists in rat neostriatum.

Authors:  J F Plantjé; A H Mulder; J C Stoof
Journal:  Eur J Pharmacol       Date:  1983-07-22       Impact factor: 4.432
  10 in total
  2 in total

Review 1.  Dopamine-receptor agonists: mechanisms underlying autoreceptor selectivity. I. Review of the evidence.

Authors:  D Clark; S Hjorth; A Carlsson
Journal:  J Neural Transm       Date:  1985       Impact factor: 3.575

2.  An electrophysiological analysis of the actions of the 3-PPP enantiomers on the nigrostriatal dopamine system.

Authors:  D Clark; G Engberg; E Pileblad; T H Svensson; A Carlsson; A S Freeman; B S Bunney
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1985-06       Impact factor: 3.000
  2 in total

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