Literature DB >> 6324785

Dexamethasone inhibits generation in inflammatory sites of the chemotactic activity attributable to leukotriene B4.

S Tsurufuji, A Kurihara, S Kiso, Y Suzuki, K Ohuchi.   

Abstract

Effects of dexamethasone on chemotactic activity to polymorphonuclear leukocytes (PMN) of a lipophilic fraction collected with the aid of octadecylsilyl silica cartridge from exudates of an allergic inflammation were investigated. The chemotactic activity of this fraction was attributable to leukotriene B4 fraction separated by means of a reversed phase high performance liquid chromatography. Local application of dexamethasone suppressed dose-dependently the chemotactic activity of the lipophilic fraction in parallel with the inhibition of PMN infiltration in the inflammatory sites.

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Year:  1984        PMID： 6324785     DOI： 10.1016/0006-291x(84)90856-8

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  6 in total

1.  Induction of neutrophil infiltration by rat chemotactic cytokine (CINC) and its inhibition by dexamethasone in rats.

Authors:  N Hirasawa; M Watanabe; S Mue; K Watanabe; S Tsurufuji; K Ohuchi
Journal:  Inflammation       Date:  1992-04       Impact factor: 4.092

2.  Vascular permeability responses and the role of prostaglandin E2 in an experimental allergic inflammation of air pouch type in rats.

Authors:  N Hirasawa; K Ohuchi; K Sugio; S Tsurufuji; M Watanabe; S Yoshino
Journal:  Br J Pharmacol       Date:  1986-04       Impact factor: 8.739

3.  Role of bradykinin in the vascular permeability response induced by carrageenin in rats.

Authors:  S Kumakura; I Kamo; S Tsurufuji
Journal:  Br J Pharmacol       Date:  1988-04       Impact factor: 8.739

4.  Stimulation of neutrophil adherence to vascular endothelial cells by histamine and thrombin and its inhibition by PAF antagonists and dexamethasone.

Authors:  M Watanabe; M Yagi; M Omata; N Hirasawa; S Mue; S Tsurufuji; K Ohuchi
Journal:  Br J Pharmacol       Date:  1991-01       Impact factor: 8.739

5.  Neutrophils from patients undergoing hip surgery exhibit enhanced movement under spinal anaesthesia compared with general anaesthesia.

Authors:  R Erskine; P K Janicki; P Ellis; M F James
Journal:  Can J Anaesth       Date:  1992-11       Impact factor: 5.063

Review 6.  The Role of Neuroinflammation in Postoperative Cognitive Dysfunction: Moving From Hypothesis to Treatment.

Authors:  Seyed A Safavynia; Peter A Goldstein
Journal:  Front Psychiatry       Date:  2019-01-17       Impact factor: 4.157
  6 in total

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