Literature DB >> 6324703

Spontaneous and induced immunoglobulin secretion by synovial fluid B lymphocytes in rheumatoid arthritis.

J Petersen, T Ingemann-Hansen, J S Halkjaer-Kristensen.   

Abstract

The functional properties of B lymphocytes in synovial fluid (SF) from patients with rheumatoid arthritis (RA) were analysed by means of a reverse haemolytic plaque forming cell (PFC) assay. SF mononuclear cells spontaneously secreted IgG, but little IgM or IgA. The SF cells failed to respond to the polyclonal B cell activators pokeweed mitogen (PWM) and Epstein-Barr virus. However, SF B cells cocultured with autologous T lymphocytes from the blood and stimulated with PWM secreted IgG but little IgM or IgA. The PFC responses of blood B cells cocultured with autologous SF T cells in the presence of PWM were low; irradiation of the T cells increased the blood B lymphocyte responses, but the differences were not statistically significant. It is concluded that suppressor SF T cells may be partly responsible for the poor response of SF B cells to PWM.

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Year:  1984        PMID： 6324703      PMCID： PMC1001450          DOI： 10.1136/ard.43.2.140

Source DB:  PubMed          Journal:  Ann Rheum Dis        ISSN： 0003-4967            Impact factor:   19.103


  25 in total

1.  Predominantly T-cell infiltrate in rheumatoid synovial membranes.

Authors:  J A Van Boxel; S A Paget
Journal:  N Engl J Med       Date:  1975-09-11       Impact factor: 91.245

2.  Identification of human mononuclear leucocyte populations by esterase staining.

Authors:  D A Horwitz; A C Allison; P Ward; N Kight
Journal:  Clin Exp Immunol       Date:  1977-11       Impact factor: 4.330

3.  Immunglobulin classes, subclasses and complexes of IgG rheumatoid factor in rheumatoid plasma cells.

Authors:  E Munthe; J B Natvig
Journal:  Clin Exp Immunol       Date:  1972-09       Impact factor: 4.330

4.  Immunological characterization of lymphocytes in synovial fluid from patients with rheumatoid arthritis.

Authors:  S S Froland; J B Natvig; G Husby
Journal:  Scand J Immunol       Date:  1973       Impact factor: 3.487

Review 5.  Plaque forming cells: methodology and theory.

Authors:  N K Jerne; C Henry; A A Nordin; H Fuji; A M Koros; I Lefkovits
Journal:  Transplant Rev       Date:  1974

6.  Establishment of cell lines from normal adult human blood leukocytes by exposure to Epstein-Barr virus and neutralization by human sera with Epstein-Barr virus antibody.

Authors:  G Miller; H Lisco; H I Kohn; D Stitt; J F Enders
Journal:  Proc Soc Exp Biol Med       Date:  1971-09

7.  A plaque assay for all cells secreting Ig of a given type or class.

Authors:  E Gronowicz; A Coutinho; F Melchers
Journal:  Eur J Immunol       Date:  1976-08       Impact factor: 5.532

8.  Gamma globulin complexes in synovial fluids of patients with rheumatoid arthritis. Partial characterization and relationship to lowered complement levels.

Authors:  R J Winchester; V Agnello; H G Kunkel
Journal:  Clin Exp Immunol       Date:  1970-05       Impact factor: 4.330

9.  In vitro synthesis of immunoglobulin by rheumatoid synovial membrane.

Authors:  J D Smiley; C Sachs; M Ziff
Journal:  J Clin Invest       Date:  1968-03       Impact factor: 14.808

10.  In vitro mitogen stimulation of synovial fluid lymphocytes from rheumatoid arthritis and juvenile rheumatoid arthritis patients: dissociation between the response to antigens and polyclonal mitogens.

Authors:  T G Abrahamsen; S S Frøland; J B Natvig
Journal:  Scand J Immunol       Date:  1978       Impact factor: 3.487
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  6 in total

1.  Spontaneous and induced immunoglobulin synthesis and anti-neutrophil cytoplasm antibodies in Wegener's granulomatosis: relation to leukocyte subpopulations in blood and active lesions.

Authors:  N Rasmussen; J Petersen; E Ralfkiaer; S Avnstøm; A Wiik
Journal:  Rheumatol Int       Date:  1988       Impact factor: 2.631

2.  Evaluation of CD5-positive B cells in blood and synovial fluid of patients with rheumatic diseases.

Authors:  J A Sowden; P J Roberts-Thomson; H Zola
Journal:  Rheumatol Int       Date:  1987       Impact factor: 2.631

3.  Correlation of anti-cytoskeleton antibody activities in synovial fluid with interleukin-6 in patients with osteoarthritis and inflammatory joint disease.

Authors:  W J Mayet; E Hermann; M Bachmann; M Manns; K H Meyer zum Büschenfelde
Journal:  Klin Wochenschr       Date:  1990-07-05

4.  C reactive protein and immunoglobulin G in synovial fluid and serum in joint disease.

Authors:  B Shine; J T Bourne; F Begum Baig; J Dacre; D V Doyle
Journal:  Ann Rheum Dis       Date:  1991-01       Impact factor: 19.103

5.  Pokeweed mitogen-induced secretion of IgG- and IgM-rheumatoid factors by synovial fluid and blood B lymphocytes in rheumatoid arthritis.

Authors:  J Petersen; C Heilmann; M Høier-Madsen
Journal:  Rheumatol Int       Date:  1986       Impact factor: 2.631

6.  Functional capacities of T lymphocyte subsets from synovial fluid and blood in rheumatoid arthritis.

Authors:  J Petersen
Journal:  Ann Rheum Dis       Date:  1986-07       Impact factor: 19.103
  6 in total

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