Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Antiviral activity of SK&F 21681 against herpes simplex virus.

Literature DB >> 6324667

Antiviral activity of SK&F 21681 against herpes simplex virus.

Abstract

SK&F 21681 (3,10-dimethyl-10-H-s-triazolo[4',3':2,3]-as-triazino-[ 5,6-b]indole) is an inhibitor of the growth of herpes simplex viruses types 1 and 2 at a concentration of 60 micrograms/ml. It inhibits the synthesis of the viral DNA and the formation of virus particles, although the viral polypeptide synthesis is not significantly affected by this compound. Mutants of herpes simplex viruses types 1 and 2 which are able to grow in the presence of SK&F 21681 were isolated. They induced normal levels of thymidine kinase and DNA polymerase activities in the infected cells and did not show resistance to either 9-[2-hydroxyethoxymethyl] guanine or phosphonoacetic acid.

Entities: Chemical

Mesh：

Substances：

Year: 1984 PMID： 6324667 PMCID： PMC185473 DOI： 10.1128/AAC.25.2.195

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

21 in total

1. The synthesis of herpes simplex virus proteins in the absence of virus DNA synthesis.

Authors: K L Powell; D J Purifoy; R J Courtney
Journal: Biochem Biophys Res Commun Date: 1975-09-02 Impact factor: 3.575

2. Regulation of herpesvirus macromolecular synthesis: sequential transition of polypeptide synthesis requires functional viral polypeptides.

Authors: R W Honess; B Roizman
Journal: Proc Natl Acad Sci U S A Date: 1975-04 Impact factor: 11.205

3. Regulation of herpesvirus macromolecular synthesis. I. Cascade regulation of the synthesis of three groups of viral proteins.

Authors: R W Honess; B Roizman
Journal: J Virol Date: 1974-07 Impact factor: 5.103

Antiviral activity of SK&F 21681 against herpes simplex virus.

1. The synthesis of herpes simplex virus proteins in the absence of virus DNA synthesis.

2. Regulation of herpesvirus macromolecular synthesis: sequential transition of polypeptide synthesis requires functional viral polypeptides.

3. Regulation of herpesvirus macromolecular synthesis. I. Cascade regulation of the synthesis of three groups of viral proteins.

4. Regulation of herpes simplex virus-induced thymidine kinase.

5. Biochemical studies on the herpes simplex virus-specified deoxypyrimidine kinase activity.

6. Rhinovirus inhibition by 3-substituted triazinoindoles.

7. Inhibition of rhinovirus by isatin thiosemicarbazone analogues.

8. Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

9. Characteristics of the BGM line of cells from African green monkey kidney. Brief report.

10. Suppression of herpes simplex virus infection by phosphonoacetic acid.

1. Antifungal properties in a novel series of triazino[5,6-b]indoles.