Literature DB >> 6324666

Inhibition of cellular alpha DNA polymerase and herpes simplex virus-induced DNA polymerases by the triphosphate of BW759U.

M H St Clair, W H Miller, R L Miller, C U Lambe, P A Furman.   

Abstract

The triphosphate form of the acyclovir analog BW759U (9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]guanine) inhibited the DNA polymerases (EC 2.7.7.7) from several strains of herpes simplex virus type 1. Two acyclovir triphosphate-resistant DNA polymerases were as sensitive to BW759U-triphosphate as were the DNA polymerases induced by wild-type viruses (Ki = 0.05 to 0.1 microM). The Ki value for cellular alpha DNA polymerase was 35- to 50-fold greater than those for the DNA polymerases induced by the various herpes simplex virus strains investigated. Incubation of Vero cells infected by the KOS strain of herpes simplex virus type 1 with the acyclovir analog resulted in the formation of substantial quantities of (9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]guanine) triphosphate.

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Year:  1984        PMID： 6324666      PMCID： PMC185472          DOI： 10.1128/AAC.25.2.191

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  16 in total

1.  DNA covalently linked to carboxymethyl-cellulose and its application in affinity chromatography.

Authors:  H Potuzak; U Wintersberger
Journal:  FEBS Lett       Date:  1976-03-15       Impact factor: 4.124

2.  Thymidine kinase from herpes simplex virus phosphorylates the new antiviral compound, 9-(2-hydroxyethoxymethyl)guanine.

Authors:  J A Fyfe; P M Keller; P A Furman; R L Miller; G B Elion
Journal:  J Biol Chem       Date:  1978-12-25       Impact factor: 5.157

3.  Human cytomegalovirus. III. Virus-induced DNA polymerase.

Authors:  E S Huang
Journal:  J Virol       Date:  1975-08       Impact factor: 5.103

4.  Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl) guanine.

Authors:  G B Elion; P A Furman; J A Fyfe; P de Miranda; L Beauchamp; H J Schaeffer
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

5.  Characterization of herpes simplex virus-induced deoxyribonucleic acid polymerase.

Authors:  A Weissbach; S C Hong; J Aucker; R Muller
Journal:  J Biol Chem       Date:  1973-09-25       Impact factor: 5.157

6.  Kinetics and intermediates in the intracellular synthesis of bacteriophage T4 deoxyribonucleic acid.

Authors:  S Altman; L S Lerman
Journal:  J Mol Biol       Date:  1970-06-14       Impact factor: 5.469

7.  Relative potencies of anti-herpes compounds.

Authors:  P Collins; D J Bauer
Journal:  Ann N Y Acad Sci       Date:  1977-03-04       Impact factor: 5.691

8.  Statistical methods to distinguish competitive, noncompetitive, and uncompetitive enzyme inhibitors.

Authors:  T Spector; G Hajian
Journal:  Anal Biochem       Date:  1981-08       Impact factor: 3.365

9.  Inhibition of cellular alpha and virally induced deoxyribonucleic acid polymerases by the triphosphate of acyclovir.

Authors:  M H St Clair; P A Furman; C M Lubbers; G B Elion
Journal:  Antimicrob Agents Chemother       Date:  1980-11       Impact factor: 5.191

10.  Acyclovir-resistant mutants of herpes simplex virus type 1 express altered DNA polymerase or reduced acyclovir phosphorylating activities.

Authors:  P A Furman; D M Coen; M H St Clair; P A Schaffer
Journal:  J Virol       Date:  1981-12       Impact factor: 5.103
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  27 in total

1.  A mouse model for X-linked adrenoleukodystrophy.

Authors:  J F Lu; A M Lawler; P A Watkins; J M Powers; A B Moser; H W Moser; K D Smith
Journal:  Proc Natl Acad Sci U S A       Date:  1997-08-19       Impact factor: 11.205

2.  Three-dimensional analysis of the synergistic cytotoxicity of ganciclovir and zidovudine.

Authors:  M N Prichard; L E Prichard; W A Baguley; M R Nassiri; C Shipman
Journal:  Antimicrob Agents Chemother       Date:  1991-06       Impact factor: 5.191

3.  The enzymological basis for resistance of herpesvirus DNA polymerase mutants to acyclovir: relationship to the structure of alpha-like DNA polymerases.

Authors:  L Huang; K K Ishii; H Zuccola; A M Gehring; C B Hwang; J Hogle; D M Coen
Journal:  Proc Natl Acad Sci U S A       Date:  1999-01-19       Impact factor: 11.205

4.  Inhibition by ganciclovir of cell growth and DNA synthesis of cells biochemically transformed with herpesvirus genetic information.

Authors:  M H St Clair; C U Lambe; P A Furman
Journal:  Antimicrob Agents Chemother       Date:  1987-06       Impact factor: 5.191

5.  Identification of amino acids in herpes simplex virus DNA polymerase involved in substrate and drug recognition.

Authors:  J S Gibbs; H C Chiou; K F Bastow; Y C Cheng; D M Coen
Journal:  Proc Natl Acad Sci U S A       Date:  1988-09       Impact factor: 11.205

6.  Characterization of the Epstein-Barr virus-encoded thymidine kinase expressed in heterologous eucaryotic and procaryotic systems.

Authors:  E Littler; J R Arrand
Journal:  J Virol       Date:  1988-10       Impact factor: 5.103

7.  Sensitivity of arabinosyladenine-resistant mutants of herpes simplex virus to other antiviral drugs and mapping of drug hypersensitivity mutations to the DNA polymerase locus.

Authors:  D M Coen; H E Fleming; L K Leslie; M J Retondo
Journal:  J Virol       Date:  1985-02       Impact factor: 5.103

8.  Metabolic activation of the nucleoside analog 9-[( 2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine in human diploid fibroblasts infected with human cytomegalovirus.

Authors:  K K Biron; S C Stanat; J B Sorrell; J A Fyfe; P M Keller; C U Lambe; D J Nelson
Journal:  Proc Natl Acad Sci U S A       Date:  1985-04       Impact factor: 11.205

9.  Reduced in vivo mutagenesis by mutant herpes simplex DNA polymerase involves improved nucleotide selection.

Authors:  J D Hall; P A Furman; M H St Clair; C W Knopf
Journal:  Proc Natl Acad Sci U S A       Date:  1985-06       Impact factor: 11.205

10.  Susceptibility to other antiherpes drugs of pathogenic variants of herpes simplex virus selected for resistance to acyclovir.

Authors:  B A Larder; G Darby
Journal:  Antimicrob Agents Chemother       Date:  1986-05       Impact factor: 5.191
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