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Literature DB >> 6324215

Class II HLA-DC beta-chain DNA restriction fragments differentiate among HLA-DR2 individuals in insulin-dependent diabetes and multiple sclerosis.

D Cohen, O Cohen, A Marcadet, C Massart, M Lathrop, I Deschamps, J Hors, E Schuller, J Dausset.

Abstract

HLA-DR2 allele is negatively associated with insulin-dependent diabetes and positively associated with multiple sclerosis (MS). A 2.2-kilobase-pair EcoRI DNA restriction fragment detected with a beta-chain HLA-DC cDNA probe was found to be strongly correlated with HLA-DR2 in the normal population, but was absent in HLA-DR2 insulin-dependent diabetic patients. This fragment was found in HLA-DR2 multiple sclerosis patients with the same frequency as in controls. A beta-chain HLA-DC 12-kilobase-pair BamHI fragment might differentiate multiple sclerosis patients from healthy individuals.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1984 PMID： 6324215 PMCID： PMC345003 DOI： 10.1073/pnas.81.6.1774

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

16 in total

Review 1. HLA and disease 1982--a survey.

Authors: A Svejgaard; P Platz; L P Ryder
Journal: Immunol Rev Date: 1983 Impact factor: 12.988

2. Gene conversion and polymorphism: generation of mouse immunoglobulin gamma 2a chain alleles by differential gene conversion by gamma 2b chain gene.

Authors: R Ollo; F Rougeon
Journal: Cell Date: 1983-02 Impact factor: 41.582

3. Allelic polymorphism and complexity of the genes for HLA-DR beta-chains--direct analysis by DNA-DNA hybridization.

Authors: C T Wake; E O Long; B Mach
Journal: Nature Date: 1982-11-25 Impact factor: 49.962

4. Polymorphic restriction endonuclease fragment segregates and correlates with the gene for HLA-B8.

Authors: H M Cann; L Ascanio; P Paul; A Marcadet; J Dausset; D Cohen
Journal: Proc Natl Acad Sci U S A Date: 1983-03 Impact factor: 11.205

5. Complete amino acid sequence of an HLA-DR antigen-like beta chain as predicted from the nucleotide sequence: similarities with immunoglobulins and HLA-A, -B, and -C antigens.

Authors: D Larhammar; L Schenning; K Gustafsson; K Wiman; L Claesson; L Rask; P A Peterson
Journal: Proc Natl Acad Sci U S A Date: 1982-06 Impact factor: 11.205

Review 6. The genetics of susceptibility to multiple sclerosis.

Authors: R S Spielman; N Nathanson
Journal: Epidemiol Rev Date: 1982 Impact factor: 6.222

7. The structure of a mutant H-2 gene suggests that the generation of polymorphism in H-2 genes may occur by gene conversion-like events.

Authors: E H Weiss; A Mellor; L Golden; K Fahrner; E Simpson; J Hurst; R A Flavell
Journal: Nature Date: 1983-02-24 Impact factor: 49.962

8. HLA and susceptibility to type I diabetes. Hypothesis.

Authors: F H Bach; M Segall; S Rich; J Barbosa
Journal: Tissue Antigens Date: 1982-07

9. Complete sequence of an HLA-dR beta chain deduced from a cDNA clone and identification of multiple non-allelic DR beta chain genes.

Authors: E O Long; C T Wake; J Gorski; B Mach
Journal: EMBO J Date: 1983 Impact factor: 11.598

Class II HLA-DC beta-chain DNA restriction fragments differentiate among HLA-DR2 individuals in insulin-dependent diabetes and multiple sclerosis.

Review 1. HLA and disease 1982--a survey.

2. Gene conversion and polymorphism: generation of mouse immunoglobulin gamma 2a chain alleles by differential gene conversion by gamma 2b chain gene.

3. Allelic polymorphism and complexity of the genes for HLA-DR beta-chains--direct analysis by DNA-DNA hybridization.

4. Polymorphic restriction endonuclease fragment segregates and correlates with the gene for HLA-B8.

5. Complete amino acid sequence of an HLA-DR antigen-like beta chain as predicted from the nucleotide sequence: similarities with immunoglobulins and HLA-A, -B, and -C antigens.

Review 6. The genetics of susceptibility to multiple sclerosis.

7. The structure of a mutant H-2 gene suggests that the generation of polymorphism in H-2 genes may occur by gene conversion-like events.

8. HLA and susceptibility to type I diabetes. Hypothesis.

9. Complete sequence of an HLA-dR beta chain deduced from a cDNA clone and identification of multiple non-allelic DR beta chain genes.

10. Polymorphism and complexity of the human DC and murine I-A alpha chain genes.

1. HLA-DQ rather than HLA-DR region might be involved in dominant nonsusceptibility to diabetes.

2. The genetic aspects of multiple sclerosis.

3. A systematic study of HLA class II-beta DNA restriction fragments in insulin-dependent diabetes mellitus.

4. Association of class II HLA-DQ beta chain DNA restriction fragments with multiple sclerosis.

5. DNA polymorphism of the C2 locus.

6. HLA-DR genotyping by restriction fragment length polymorphism analyses.

7. T-cell receptor V alpha and C alpha alleles associated with multiple and myasthenia gravis.

Review 8. Structural variation among major histocompatibility complex class-II genes which predispose to autoimmunity.

Review 9. Molecular biology of type 1 (insulin-dependent) diabetes mellitus.

Review 10. Mechanisms of autoimmunity in insulin-dependent diabetes mellitus.