Literature DB >> 6324202

Interaction of calcium channel blockers with non-neuronal benzodiazepine binding sites.

E H Cantor, A Kenessey, G Semenuk, S Spector.   

Abstract

The ability of calcium channel blockers to displace the binding of benzodiazepine ligands was investigated in rat heart, kidney, and brain. The dihydropyridine calcium channel blockers nifedipine and nitrendipine displaced the binding of the non-neuronal-site ligand [3H]Ro5-4864, but not that of the neuronal-site ligands [3H]flurazepam or [3H]clonazepam. The inhibition was competitive, with Ki values in the micromolar range. Other calcium channel blockers--i.e., verapamil and diltiazem--were inactive at both sites. Thus, non-neuronal benzodiazepines bind to a class of sites that also binds dihydropyridines. This implies a role for benzodiazepines in the mediation of calcium-dependent phenomena.

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Year:  1984        PMID： 6324202      PMCID： PMC344874          DOI： 10.1073/pnas.81.5.1549

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  30 in total

1.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
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2.  Specific binding of [3H]nitrendipine to membranes from coronary arteries and heart in relation to pharmacological effects. Paradoxical stimulation by diltiazem.

Authors:  A DePover; M A Matlib; S W Lee; G P Dubé; I L Grupp; G Grupp; A Schwartz
Journal:  Biochem Biophys Res Commun       Date:  1982-09-16       Impact factor: 3.575

3.  Characterization of peripheral-type benzodiazepine binding sites in brain using [3H]Ro 5-4864.

Authors:  P J Marangos; J Patel; J P Boulenger; R Clark-Rosenberg
Journal:  Mol Pharmacol       Date:  1982-07       Impact factor: 4.436

4.  Properties of two benzodiazepine binding sites in spinal cord.

Authors:  M Del Zompo; R M Post; J F Tallman
Journal:  Neuropharmacology       Date:  1983-01       Impact factor: 5.250

5.  Does the organic calcium channel blocker D600 act from inside or outside on the cardiac cell membrane?

Authors:  J Hescheler; D Pelzer; G Trube; W Trautwein
Journal:  Pflugers Arch       Date:  1982-06       Impact factor: 3.657

6.  Micromolar affinity benzodiazepine receptors: identification and characterization in central nervous system.

Authors:  A C Bowling; R J DeLorenzo
Journal:  Science       Date:  1982-06-11       Impact factor: 47.728

7.  Specific calcium antagonist binding sites in brain.

Authors:  P J Marangos; J Patel; C Miller; A M Martino
Journal:  Life Sci       Date:  1982-10-11       Impact factor: 5.037

8.  Characterization of binding of the Ca++ channel antagonist, [3H]nitrendipine, to guinea-pig ileal smooth muscle.

Authors:  G T Bolger; P Gengo; R Klockowski; E Luchowski; H Siegel; R A Janis; A M Triggle; D J Triggle
Journal:  J Pharmacol Exp Ther       Date:  1983-05       Impact factor: 4.030

9.  The binding of [3H]-diazepam to guinea-pig ileal longitudinal muscle and the in vitro inhibition of contraction by benzodiazepines.

Authors:  J P Hullihan; S Spector; T Taniguchi; J K Wang
Journal:  Br J Pharmacol       Date:  1983-02       Impact factor: 8.739

10.  Identification of voltage operated calcium channels by binding studies: differentiation of subclasses of calcium antagonist drugs with 3H-nimodipine radioligand binding.

Authors:  H Glossmann; D R Ferry; F Lübbecke; R Mewes; F Hofmann
Journal:  J Recept Res       Date:  1983
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  7 in total

1.  Effect of benzodiazepines on the proliferation of mouse spleen lymphocytes in vitro.

Authors:  M Pawlikowski; K Lysoń; J Kunert-Radek; H Stepień
Journal:  J Neural Transm       Date:  1988       Impact factor: 3.575

Review 2.  Molecular biology of inhibitory amino acid receptors.

Authors:  R S Duman; P M Sweetnam; P A Gallombardo; J F Tallman
Journal:  Mol Neurobiol       Date:  1987 Spring-Summer       Impact factor: 5.590

3.  Pharmacological relevance of peripheral type benzodiazepine receptors on motor nerve and skeletal muscle.

Authors:  L C Chiou; C C Chang
Journal:  Br J Pharmacol       Date:  1994-05       Impact factor: 8.739

4.  A novel 1,4-dihydropyridine-binding site on mitochondrial membranes from guinea-pig heart, liver and kidney.

Authors:  G Zernig; H Glossmann
Journal:  Biochem J       Date:  1988-07-01       Impact factor: 3.857

5.  Nitrendipine decreases benzodiazepine withdrawal seizures but not the development of benzodiazepine tolerance or withdrawal signs.

Authors:  S J Dolin; T L Patch; M Rabbani; R J Siarey; A R Bowhay; H J Little
Journal:  Br J Pharmacol       Date:  1990-11       Impact factor: 8.739

6.  Specific ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in human colorectal cancer cells.

Authors:  K Maaser; M Höpfner; A Jansen; G Weisinger; M Gavish; A P Kozikowski; A Weizman; P Carayon; E O Riecken; M Zeitz; H Scherübl
Journal:  Br J Cancer       Date:  2001-11-30       Impact factor: 7.640

7.  Developmental expression of translocator protein/peripheral benzodiazepine receptor in reproductive tissues.

Authors:  Kanako Morohaku; Newton S Phuong; Vimal Selvaraj
Journal:  PLoS One       Date:  2013-09-05       Impact factor: 3.240
  7 in total

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