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Literature DB >> 6324189

beta-endorphin-(1-27) is an antagonist of beta-endorphin analgesia.

Abstract

beta h-Endorphin-(1-27), a naturally occurring fragment of human beta-endorphin (beta h-endorphin), diminishes the analgesic effect of beta h-endorphin when coinjected intra-cerebroventricularly into mice. A parallel shift in the dose-response curve of beta h-endorphin in the presence of beta h-endorphin-(1-27) suggests competition at the same site. The potency of beta h-endorphin-(1-27) in antagonizing analgesia is greater than 4 times greater than that of the opiate antagonist naloxone.

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Year: 1984 PMID： 6324189 PMCID： PMC344839 DOI： 10.1073/pnas.81.5.1389

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

17 in total

1. beta-Endorphin: characteristics of binding sites in the rat brain.

Authors: P Ferrara; R Houghten; C H Li
Journal: Biochem Biophys Res Commun Date: 1979-08-13 Impact factor: 3.575

2. Analgesic activity of lipotropin C fragment depends on carboxyl terminal tetrapeptide.

Authors: M J Geisow; J F Deakin; J O Dostrovsky; D G Smyth
Journal: Nature Date: 1977-09-08 Impact factor: 49.962

3. beta-endorphin is a potent analgesic agent.

Authors: H H Loh; L F Tseng; E Wei; C H Li
Journal: Proc Natl Acad Sci U S A Date: 1976-08 Impact factor: 11.205

4. Distribution of active and inactive forms of endorphins in rat pituitary and brain.

Authors: S Zakarian; D Smyth
Journal: Proc Natl Acad Sci U S A Date: 1979-11 Impact factor: 11.205

5. Quantitative studies of the antagonism of morphine by nalorphine and naloxone.

Authors: A E Takemori; H J Kupferberg; J W Miller
Journal: J Pharmacol Exp Ther Date: 1969-09 Impact factor: 4.030

6. C-fragment of lipotropin--an endogenous potent analgesic peptide.

Authors: W Feldberg; D G Smyth
Journal: Br J Pharmacol Date: 1977-07 Impact factor: 8.739

7. Synthesis and analgesic activity of human beta-endorphin.

Authors: C H Li; D Yamashiro; L F Tseng; H H Loh
Journal: J Med Chem Date: 1977-03 Impact factor: 7.446

8. Peptide inhibitor of morphine- and beta-endorphin-induced analgesia.

Authors: N M Lee; H J Friedman; L Leybin; T M Cho; H H Loh; C H Li
Journal: Proc Natl Acad Sci U S A Date: 1980-09 Impact factor: 11.205

9. beta-Endorphin- (1-27): acetylation of alpha-amino groups enhances immunoreactivity but diminishes analgesic and receptor-binding activities with no changes in circular dichroism spectra.

Authors: C H Li; L F Tseng; M D Jibson; R G Hammonds; D Yamashiro; M Zaoral
Journal: Biochem Biophys Res Commun Date: 1980-12-16 Impact factor: 3.575

10. Isolation of the C-fragment and C'-fragment of lipotropin from pig pituitary and C-fragment from brain.

Authors: D G Smyth; C R Snell; D E Massey
Journal: Biochem J Date: 1978-10-01 Impact factor: 3.857

11 in total

1. Beta-endorphin-(1-27) is a naturally occurring antagonist of the reinforcing effects of opioids.

Authors: R Bals-Kubik; A Herz; T S Shippenberg
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1988-10 Impact factor: 3.000

Review 2. Five Decades of Research on Opioid Peptides: Current Knowledge and Unanswered Questions.

Authors: Lloyd D Fricker; Elyssa B Margolis; Ivone Gomes; Lakshmi A Devi
Journal: Mol Pharmacol Date: 2020-06-02 Impact factor: 4.436

3. Inhibition of spinal opioid antinociception by intrathecal beta-endorphin1-27 in the rat.

Authors: M Hong; M Sutak; K Jhamandas
Journal: Br J Pharmacol Date: 1993-04 Impact factor: 8.739

Review 4. Neuropeptides: animal behaviour and human psychopathology.

Authors: D de Wied; J M van Ree
Journal: Eur Arch Psychiatry Neurol Sci Date: 1989

5. Beta-endorphin-(1-27) is a naturally occurring antagonist to etorphine-induced analgesia.

Authors: P Nicolas; C H Li
Journal: Proc Natl Acad Sci U S A Date: 1985-05 Impact factor: 11.205

6. beta-Endorphin-induced analgesia is inhibited by synthetic analogs of beta-endorphin.

Authors: P Nicolas; R G Hammonds; C H Li
Journal: Proc Natl Acad Sci U S A Date: 1984-05 Impact factor: 11.205

7. Isolation, sequencing, synthesis, and pharmacological characterization of two brain neuropeptides that modulate the action of morphine.

Authors: H Y Yang; W Fratta; E A Majane; E Costa
Journal: Proc Natl Acad Sci U S A Date: 1985-11 Impact factor: 11.205