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Literature DB >> 6324094

Organization of the transcriptional unit of a human class II histocompatibility antigen: HLA-DR heavy chain.

A Schamboeck, A J Korman, A Kamb, J L Strominger.

Abstract

A total of 5724 base pairs of a recombinant phage DNA containing a human HLA-DR heavy chain gene including flanking regions has been analyzed. The regions corresponding to all the exons have been identified. The sites of initiation of transcription and polyadenylation have been determined. A large intron of 2399 base pairs separates the first exon containing the 5' untranslated region and the signal peptide from the second exon containing the N-terminal peptide domain.

Entities: Gene Species

Mesh：

Substances：

Year: 1983 PMID： 6324094 PMCID： PMC326615 DOI： 10.1093/nar/11.24.8663

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

38 in total

Review 1. MHC-restricted cytotoxic T cells: studies on the biological role of polymorphic major transplantation antigens determining T-cell restriction-specificity, function, and responsiveness.

Authors: R M Zinkernagel; P C Doherty
Journal: Adv Immunol Date: 1979 Impact factor: 3.543

2. Immunological surveillance against altered self components by sensitised T lymphocytes in lymphocytic choriomeningitis.

Authors: R M Zinkernagel; P C Doherty
Journal: Nature Date: 1974-10-11 Impact factor: 49.962

3. Structural studies on the murine Ia alloantigens--III. Tryptic peptide comparisons of allelic products of the I-E/C sub-region.

Authors: R G Cook; E S Vitetta; J W Uhr; J D Capra
Journal: Mol Immunol Date: 1979-01 Impact factor: 4.407

Review 4. Role of MHC gene products in immune regulation.

Authors: B Benacerraf
Journal: Science Date: 1981-06-12 Impact factor: 47.728

Review 5. Organization and expression of eucaryotic split genes coding for proteins.

Authors: R Breathnach; P Chambon
Journal: Annu Rev Biochem Date: 1981 Impact factor: 23.643

6. Sequencing end-labeled DNA with base-specific chemical cleavages.

Authors: A M Maxam; W Gilbert
Journal: Methods Enzymol Date: 1980 Impact factor: 1.600

7. The isolation and characterization of linked delta- and beta-globin genes from a cloned library of human DNA.

Authors: R M Lawn; E F Fritsch; R C Parker; G Blake; T Maniatis
Journal: Cell Date: 1978-12 Impact factor: 41.582

8. Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA.

Authors: C Auffray; F Rougeon
Journal: Eur J Biochem Date: 1980-06

9. Polymorphism and complexity of the human DC and murine I-A alpha chain genes.

Authors: C Auffray; A Ben-Nun; M Roux-Dosseto; R N Germain; J G Seidman; J L Strominger
Journal: EMBO J Date: 1983 Impact factor: 11.598

10. Immunological dissection of human Ia molecules.

Authors: R Tosi; N Tanigaki; D Centis; G B Ferrara; D Pressman
Journal: J Exp Med Date: 1978-12-01 Impact factor: 14.307

38 in total

1. Methylation state of the human HLA-DRa gene in transgenic mice.

Authors: G Feriotto; L Pozzi; F Deledda; R Barbieri; R Piva; C Nastruzzi; A Ciucci; P G Natali; P Giacomini; R Gambari
Journal: Cytotechnology Date: 1991-02 Impact factor: 2.058

2. Point mutations define positions in HLA-DR3 molecules that affect antigen presentation.

Authors: E Mellins; B Arp; D Singh; B Carreno; L Smith; A H Johnson; D Pious
Journal: Proc Natl Acad Sci U S A Date: 1990-06 Impact factor: 11.205

3. Transcription analysis of class II human leukocyte antigen genes from normal and immunodeficient B lymphocytes, using polymerase chain reaction.

Authors: M Bull; A van Hoef; J Gorski
Journal: Mol Cell Biol Date: 1990-07 Impact factor: 4.272

Organization of the transcriptional unit of a human class II histocompatibility antigen: HLA-DR heavy chain.

Review 1. MHC-restricted cytotoxic T cells: studies on the biological role of polymorphic major transplantation antigens determining T-cell restriction-specificity, function, and responsiveness.

2. Immunological surveillance against altered self components by sensitised T lymphocytes in lymphocytic choriomeningitis.

3. Structural studies on the murine Ia alloantigens--III. Tryptic peptide comparisons of allelic products of the I-E/C sub-region.

Review 4. Role of MHC gene products in immune regulation.

Review 5. Organization and expression of eucaryotic split genes coding for proteins.

6. Sequencing end-labeled DNA with base-specific chemical cleavages.

7. The isolation and characterization of linked delta- and beta-globin genes from a cloned library of human DNA.

8. Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA.

9. Polymorphism and complexity of the human DC and murine I-A alpha chain genes.

10. Immunological dissection of human Ia molecules.

1. Methylation state of the human HLA-DRa gene in transgenic mice.

2. Point mutations define positions in HLA-DR3 molecules that affect antigen presentation.

3. Transcription analysis of class II human leukocyte antigen genes from normal and immunodeficient B lymphocytes, using polymerase chain reaction.

4. Conservation of the promoter region of DRA-like genes from nonhuman primates.

5. Regulatory factor-X binding to mutant HLA-DRA promoter sequences.

6. Expression of human class II major histocompatibility complex antigens using retrovirus vectors.

7. Characterization of an HLA-DR beta pseudogene in the DRw52 supertypic group.

8. Methylation patterns of HLA-DR alpha genes in six mononuclear cell lines.

9. Hypomethylation of the human HLA-DR alpha gene in breast carcinomas and autologous metastases.

10. Zebrafish Mhc class II alpha chain-encoding genes: polymorphism, expression, and function.