Literature DB >> 6323990

Messenger RNA from human brain induces drug- and voltage-operated channels in Xenopus oocytes.

C B Gundersen, R Miledi, I Parker.   

Abstract

Sodium channels and receptors to serotonin and kainate were 'transplanted' from human brain into frog oocytes, by isolating messenger RNA from a fetal brain, and injecting it into Xenopus laevis oocytes. The mRNA was translated by the oocyte and induced the appearance of functional receptors and channels in its membrane. This approach renders drug- and voltage-operated channels of the human brain more amenable to detailed study.

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Year:  1984        PMID： 6323990     DOI： 10.1038/308421a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  47 in total

1.  Microtransplantation of membranes from cultured cells to Xenopus oocytes: a method to study neurotransmitter receptors embedded in native lipids.

Authors:  Eleonora Palma; Flavia Trettel; Sergio Fucile; Massimiliano Renzi; Ricardo Miledi; Fabrizio Eusebi
Journal:  Proc Natl Acad Sci U S A       Date:  2003-02-20       Impact factor: 11.205

2.  Effects of defolliculation on membrane current responses of Xenopus oocytes.

Authors:  R Miledi; R M Woodward
Journal:  J Physiol       Date:  1989-09       Impact factor: 5.182

3.  Exogenous mRNA encoding tetanus or botulinum neurotoxins expressed in Aplysia neurons.

Authors:  S Mochida; B Poulain; U Eisel; T Binz; H Kurazono; H Niemann; L Tauc
Journal:  Proc Natl Acad Sci U S A       Date:  1990-10       Impact factor: 11.205

4.  Molecular cloning, chromosomal mapping, and functional expression of human brain glutamate receptors.

Authors:  W Sun; A V Ferrer-Montiel; A F Schinder; J P McPherson; G A Evans; M Montal
Journal:  Proc Natl Acad Sci U S A       Date:  1992-02-15       Impact factor: 11.205

Review 5.  Heterologous expression of calcium channels.

Authors:  J Nargeot; N Dascal; H A Lester
Journal:  J Membr Biol       Date:  1992-03       Impact factor: 1.843

6.  Expression of functional receptors by the human gamma-aminobutyric acid A gamma 2 subunit.

Authors:  Ataúlfo Martínez-Torres; Ricardo Miledi
Journal:  Proc Natl Acad Sci U S A       Date:  2004-02-23       Impact factor: 11.205

Review 7.  Use of Xenopus oocytes for the functional expression of plasma membrane proteins.

Authors:  E Sigel
Journal:  J Membr Biol       Date:  1990-09       Impact factor: 1.843

8.  Receptors of the serotonin 1C subtype expressed from cloned DNA mediate the closing of K+ membrane channels encoded by brain mRNA.

Authors:  M M Panicker; I Parker; R Miledi
Journal:  Proc Natl Acad Sci U S A       Date:  1991-03-15       Impact factor: 11.205

9.  Expression of functional neurotransmitter receptors in Xenopus oocytes after injection of human brain membranes.

Authors:  Ricardo Miledi; Fabrizio Eusebi; Ataúlfo Martínez-Torres; Eleonora Palma; Flavia Trettel
Journal:  Proc Natl Acad Sci U S A       Date:  2002-09-17       Impact factor: 11.205

10.  Neurotransmitter receptors and voltage-dependent Ca2+ channels encoded by mRNA from the adult corpus callosum.

Authors:  C Matute; R Miledi
Journal:  Proc Natl Acad Sci U S A       Date:  1993-04-15       Impact factor: 11.205
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