Literature DB >> 6323765

Differential phosphorylation of cytoplasmic and nuclear variants of simian virus 40 large T antigen encoded by simian virus 40-adenovirus 7 hybrid viruses.

K H Scheidtmann, J Schickedanz, G Walter, R E Lanford, J S Butel.   

Abstract

The phosphorylation patterns of cytoplasmic and nuclear forms of simian virus 40 large T antigen encoded by simian virus 40-adenovirus 7 hybrid viruses were analyzed by two-dimensional peptide mapping. The PARA(cT) mutant which encodes a large T antigen defective for nuclear transport was used as source for cytoplasmic large T antigen. The data suggest that the large T antigen is phosphorylated in a sequential manner at a subset of sites in the cytoplasm and at additional sites in the nucleus.

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Year:  1984        PMID： 6323765      PMCID： PMC255692     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  27 in total

1.  Phosphorylation of T-antigen and control T-antigen expression in cells transformed by wild-type and tsA mutants of simian virus 40.

Authors:  C A Edwards; G Khoury; R G Martin
Journal:  J Virol       Date:  1979-02       Impact factor: 5.103

2.  Regulation of tumor antigen synthesis by simain virus 40 gene A.

Authors:  P Tegtmeyer; M Schwartz; J K Collins; K Rundell
Journal:  J Virol       Date:  1975-07       Impact factor: 5.103

3.  Cell surface location of simian virus 40-specific proteins on HeLa cells infected with adenovirus type 2-simian virus 40 hybrid viruses Ad2+ND1 and Ad2+ND2.

Authors:  W Deppert; R Pates
Journal:  J Virol       Date:  1979-08       Impact factor: 5.103

4.  Antigenic relationship of SV40 early proteins to purified large T polypeptide.

Authors:  R E Lanford; J S Butel
Journal:  Virology       Date:  1979-09       Impact factor: 3.616

5.  Biochemical characterization of nuclear and cytoplasmic forms of SV40 tumor antigens encoded by parental and transport-detective mutant SV40-adenovirus 7 hybrid viruses.

Authors:  R E Lanford; J S Butel
Journal:  Virology       Date:  1980-09       Impact factor: 3.616

6.  Inhibition of nuclear migration of wild-type SV40 tumor antigen by a transport-defective mutant of SV40-adenovirus 7 hybrid virus.

Authors:  R E Lanford; J S Butel
Journal:  Virology       Date:  1980-09       Impact factor: 3.616

7.  Regulation of simian virus 40 transcription: sensitive analysis of the RNA species present early in infections by virus or viral DNA.

Authors:  B A Parker; G R Stark
Journal:  J Virol       Date:  1979-08       Impact factor: 5.103

8.  The outer boundary of the cytoskeleton: a lamina derived from plasma membrane proteins.

Authors:  A Ben-Ze'ev; A Duerr; F Solomon; S Penman
Journal:  Cell       Date:  1979-08       Impact factor: 41.582

9.  Evidence for simian virus 40 (SV40) coding of SV40 T-antigen and the SV40-specific proteins in HeLa cells infected with nondefective adenovirus type 2-SV40 hybrid viruses.

Authors:  K Mann; T Hunter; G Walter; H Linke
Journal:  J Virol       Date:  1977-10       Impact factor: 5.103

10.  Antigenic and immunogenic characteristics of nuclear and membrane-associated simian virus 40 tumor antigen.

Authors:  H R Soule; R E Lanford; J S Butel
Journal:  J Virol       Date:  1980-02       Impact factor: 5.103
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  20 in total

1.  Phenotype-specific phosphorylation of simian virus 40 tsA mutant large T antigens in tsA N-type and A-type transformants.

Authors:  U Knippschild; J Kiefer; T Patschinsky; W Deppert
Journal:  J Virol       Date:  1991-08       Impact factor: 5.103

2.  Protein phosphatase 2A dephosphorylates simian virus 40 large T antigen specifically at residues involved in regulation of DNA-binding activity.

Authors:  K H Scheidtmann; D M Virshup; T J Kelly
Journal:  J Virol       Date:  1991-04       Impact factor: 5.103

3.  Removal of serine phosphates from simian virus 40 large T antigen increases its ability to stimulate DNA replication in vitro but has no effect on ATPase and DNA binding.

Authors:  F A Grässer; K Mann; G Walter
Journal:  J Virol       Date:  1987-11       Impact factor: 5.103

4.  Dimers and complexes with p53 are the prevalent oligomeric forms of a transforming nonkaryophilic T antigen of simian virus 40.

Authors:  M Montenarh; C Vesco; K H Scheidtmann
Journal:  J Virol       Date:  1987-03       Impact factor: 5.103

5.  Analysis of simian virus 40 small t antigen-induced progression of rat F111 cells minimally transformed by large T antigen.

Authors:  J Zerrahn; W Deppert
Journal:  J Virol       Date:  1993-03       Impact factor: 5.103

6.  Mutations in the phosphorylation sites of simian virus 40 (SV40) T antigen alter its origin DNA-binding specificity for sites I or II and affect SV40 DNA replication activity.

Authors:  J Schneider; E Fanning
Journal:  J Virol       Date:  1988-05       Impact factor: 5.103

7.  Biochemical characterization of phosphorylation site mutants of simian virus 40 large T antigen: evidence for interaction between amino- and carboxy-terminal domains.

Authors:  K H Scheidtmann; M Buck; J Schneider; D Kalderon; E Fanning; A E Smith
Journal:  J Virol       Date:  1991-03       Impact factor: 5.103

8.  Genetic analysis of polyomavirus large T nuclear localization: nuclear localization is required for productive association with pRb family members.

Authors:  S H Howes; B J Bockus; B S Schaffhausen
Journal:  J Virol       Date:  1996-06       Impact factor: 5.103

9.  BK virus as a cofactor in the etiology of prostate cancer in its early stages.

Authors:  Dweepanita Das; Kirk Wojno; Michael J Imperiale
Journal:  J Virol       Date:  2007-12-26       Impact factor: 5.103

10.  Polyomavirus large T antigen induces alterations in cytoplasmic signalling pathways involving Shc activation.

Authors:  V Gottifredi; G Pelicci; E Munarriz; R Maione; P G Pelicci; P Amati
Journal:  J Virol       Date:  1999-02       Impact factor: 5.103
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