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Literature DB >> 6323722

It is Rous sarcoma virus protein P12 and not P19 that binds tightly to Rous sarcoma virus RNA.

Abstract

The interactions between Rous Sarcoma virus (RSV) RNA and the viral proteins in the virus have been analysed by Sen & Todaro (1977) using ultraviolet light irradiation; they showed that the major protein ultraviolet light cross-linked to the viral RNA was P19 as identified by polyacrylamide gel electrophoresis. We report here that it is not viral protein P19 but P12 that binds tightly to RSV RNA upon ultraviolet light irradiation of the virus. Therefore, the binding sites of the viral protein along RSV RNA that we have characterized previously should be correctly attributed now to P12 and not P19.

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Year: 1984 PMID： 6323722 DOI： 10.1016/0022-2836(84)90396-6

Source DB: PubMed Journal: J Mol Biol ISSN： 0022-2836 Impact factor: 5.469

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Cited

35 in total

1. Binding of human immunodeficiency virus type 1 (HIV-1) RNA to recombinant HIV-1 gag polyprotein.

Authors: J Luban; S P Goff
Journal: J Virol Date: 1991-06 Impact factor: 5.103

2. Viral RNA annealing activities of human immunodeficiency virus type 1 nucleocapsid protein require only peptide domains outside the zinc fingers.

Authors: H De Rocquigny; C Gabus; A Vincent; M C Fournié-Zaluski; B Roques; J L Darlix
Journal: Proc Natl Acad Sci U S A Date: 1992-07-15 Impact factor: 11.205

It is Rous sarcoma virus protein P12 and not P19 that binds tightly to Rous sarcoma virus RNA.

1. Binding of human immunodeficiency virus type 1 (HIV-1) RNA to recombinant HIV-1 gag polyprotein.

2. Viral RNA annealing activities of human immunodeficiency virus type 1 nucleocapsid protein require only peptide domains outside the zinc fingers.

3. Properties of avian retrovirus particles defective in viral protease.

4. Molecular cloning and characterization of the RNA packaging-defective retrovirus SE21Q1b.

5. Role of the gag polyprotein precursor in packaging and maturation of Rous sarcoma virus genomic RNA.

6. Rous sarcoma virus nucleic acid-binding protein p12 is necessary for viral 70S RNA dimer formation and packaging.

7. A study of the dimer formation of Rous sarcoma virus RNA and of its effect on viral protein synthesis in vitro.

8. Sequence-specific binding of human immunodeficiency virus type 1 nucleocapsid protein to short oligonucleotides.

9. Mutations in Rous sarcoma virus nucleocapsid protein p12 (NC): deletions of Cys-His boxes.

10. Analytical study of avian reticuloendotheliosis virus dimeric RNA generated in vivo and in vitro.