| Literature DB >> 6322860 |
R Korenstein, D Somjen, H Fischler, I Binderman.
Abstract
Pulsed electric stimulation, coupled capacitively to bone cells isolated from rat embryo calvaria, caused changes in the intracellular level of cyclic AMP and enhanced DNA synthesis. The capacitive method of electrical stimulation was characterized in terms of displacement currents (0.7-4.0 A) and voltages (10-54 V/cm) prevailing in the stimulation chamber. Changes, both in cyclic AMP and in incorporation of [3H]thymidine into DNA, were correlated with the strength of the applied electric field. Unlike the mechanical stimulation of bone cells, the electrical stimulus was not mediated by de novo synthesis of prostaglandins. The findings suggest that cyclic-AMP changes, induced by the capacitive electrical stimulation of bone cells, trigger DNA synthesis.Entities:
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Year: 1984 PMID： 6322860 DOI： 10.1016/0167-4889(84)90121-6
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002