Literature DB >> 6322548

Induction of collagenase synthesis in chondrocytes by a factor synthesized by inflamed synovial tissue.

S S Kerwar, S C Ridge, M J Landes, J C Nolan, A L Oronsky.   

Abstract

Rabbit inflamed synovial tissue grown in culture synthesizes a factor that induces collagenase synthesis in chondrocytes and in cartilage. Synthesis of this factor by the synovial tissue is inhibited by cycloheximide but not by indomethacin. The factor has an apparent molecular weight of 30,000, is stable to heat and to trypsin treatment but is inactivated by acid. Induction of collagenase synthesis in chondrocytes occurs after a lag period of 6 hours.

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Year:  1984        PMID： 6322548     DOI： 10.1007/bf01966833

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  16 in total

1.  Synthesis of a collagenase inhibitor by smooth muscle cells in culture.

Authors:  J C Nolan; S Ridge; A L Oronsky; L L Slakey; S S Kerwar
Journal:  Biochem Biophys Res Commun       Date:  1978-08-14       Impact factor: 3.575

2.  Synthesis of collagenase and neutral proteases by articular chondrocytes: stimulation by a macrophage-derived factor.

Authors:  K Deshmukh-Phadke; M Lawrence; S Nanda
Journal:  Biochem Biophys Res Commun       Date:  1978-11-14       Impact factor: 3.575

3.  Collagenase production by lymphokine-activated macrophages.

Authors:  L M Wahl; S M Wahl; S E Mergenhagen; G R Martin
Journal:  Science       Date:  1975-01-24       Impact factor: 47.728

4.  Induction of the synthesis of latent collagenase and latent neutral protease in chondrocytes by a factor synthesized by activated macrophages.

Authors:  S C Ridge; A L Oronsky; S S Kerwar
Journal:  Arthritis Rheum       Date:  1980-04

5.  The site of cartilage matrix degradation.

Authors:  J T Dingle; T T Dingle
Journal:  Biochem J       Date:  1980-08-15       Impact factor: 3.857

6.  The progeny of rabbit articular chondrocytes synthesize collagen types I and III and type I trimer, but not type II. Verifications by cyanogen bromide peptide analysis.

Authors:  P D Benya; S R Padilla; M E Nimni
Journal:  Biochemistry       Date:  1977-03-08       Impact factor: 3.162

7.  Macrophage-fibroblast interactions in collagenase production and cartilage degradation.

Authors:  G Huybrechts-Godin; P Hauser; G Vaes
Journal:  Biochem J       Date:  1979-12-15       Impact factor: 3.857

8.  Human mononuclear cell factors mediate cartilage matrix degradation through chondrocyte activation.

Authors:  H E Jasin; J T Dingle
Journal:  J Clin Invest       Date:  1981-09       Impact factor: 14.808

9.  Destruction of articular cartilage by arthritic synovium in vitro: mechanism of breakdown and effect of indomethacin and prednisolone.

Authors:  J Panagides; M J Landes; A E Sloboda
Journal:  Agents Actions       Date:  1980-04

10.  Stimulation of rheumatoid synovial cell collagenase and prostaglandin production by partially purified lymphocyte-activating factor (interleukin 1).

Authors:  S B Mizel; J M Dayer; S M Krane; S E Mergenhagen
Journal:  Proc Natl Acad Sci U S A       Date:  1981-04       Impact factor: 11.205
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