| Literature DB >> 6322378 |
Y Kawahara, J Yamanishi, H Fukuzaki.
Abstract
During thrombin-induced serotonin release from platelets, phosphorylation of myosin light chain was increased. This protein phosphorylation, which is initiated by Ca2+ mobilization, and serotonin release were inhibited progressively by increasing concentrations of sodium nitroprusside, a potent stimulator of platelet guanylate cyclase, or 8-bromo-cyclic GMP. Thrombin-induced increase in cytoplasmic free Ca2+, which was also inhibited by these drugs in a dose-dependent manner. These results provide evidence that an increase in platelet cyclic GMP inhibits thrombin-induced Ca2+ mobilization and prevents platelet activation.Entities:
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Year: 1984 PMID： 6322378 DOI： 10.1016/0049-3848(84)90181-6
Source DB: PubMed Journal: Thromb Res ISSN： 0049-3848 Impact factor: 3.944