Literature DB >> 6322373

Postburn immunosuppression in an animal model. II. Restoration of cell-mediated immunity by immunomodulating drugs.

J Hansbrough, V Peterson, R Zapata-Sirvent, H N Claman.   

Abstract

We used a model of full-thickness burn injury in the mouse and quantitated cell-mediated immunity (CMI) by measuring the degree of sensitization to the contact antigen, 2,4-dinitrofluorobenzene (DNFB). Our previous studies have shown that CMI in the burned mouse is severely suppressed. Using this immunosuppression model, we were able to significantly restore CMI by treating animals following the burn injury either with one of the nonsteroidal anti-inflammatory drugs ibuprofen or indomethacin or with the cytotoxic alkylating agent cyclophosphamide. These drugs probably restore CMI by inhibiting generation of suppressor T lymphocytes in the burned host.

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Year:  1984        PMID： 6322373

Source DB:  PubMed          Journal:  Surgery        ISSN： 0039-6060            Impact factor:   3.982


  13 in total

Review 1.  The role of mediators in the response to thermal injury.

Authors:  Y K Youn; C LaLonde; R Demling
Journal:  World J Surg       Date:  1992 Jan-Feb       Impact factor: 3.352

Review 2.  Immunosuppression in the surgical patient.

Authors:  W Browder; D Williams
Journal:  J Natl Med Assoc       Date:  1988-05       Impact factor: 1.798

3.  Effect of an immunomodulating agent, RU 414740, on polymorphonuclear responsiveness after burn injury.

Authors:  M Roch-Arveiller; J Fontagne; A el Abbouyi; D Raichvarg; J P Giroud
Journal:  Inflammation       Date:  1991-12       Impact factor: 4.092

4.  The beneficial effects of recombinant human insulin-like growth factor-I (IGF-I) on wound healing in severely wounded senescent mice.

Authors:  S Koshizuka; K Kanazawa; N Kobayashi; I Takazawa; Y Waki; H Shibusawa; S Shumiya
Journal:  Surg Today       Date:  1997       Impact factor: 2.549

Review 5.  Need for immunologic stimulators during immunosuppression produced by major cancer surgery.

Authors:  W H Cole; L Humphrey
Journal:  Ann Surg       Date:  1985-07       Impact factor: 12.969

Review 6.  Ibuprofen in acute-care therapy.

Authors:  W B Rockwell; H P Ehrlich
Journal:  Ann Surg       Date:  1990-01       Impact factor: 12.969

7.  The influence of intestinal flora on wound healing in mice.

Authors:  M Okada
Journal:  Surg Today       Date:  1994       Impact factor: 2.549

8.  Suppression of in vitro lymphocyte and neutrophil responses by a low molecular weight suppressor active peptide from burn-patient sera.

Authors:  A N Ozkan; J L Ninnemann
Journal:  J Clin Immunol       Date:  1985-05       Impact factor: 8.317

9.  Inadequate interleukin 2 production. A fundamental immunological deficiency in patients with major burns.

Authors:  J J Wood; M L Rodrick; J B O'Mahony; S B Palder; I Saporoschetz; P D'Eon; J A Mannick
Journal:  Ann Surg       Date:  1984-09       Impact factor: 12.969

10.  The role of prostaglandin E2 in immune suppression following injury.

Authors:  J T Grbic; J A Mannick; D B Gough; M L Rodrick
Journal:  Ann Surg       Date:  1991-09       Impact factor: 12.969
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