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Literature DB >> 6322295

Amphiphilic secondary structure: design of peptide hormones.

Abstract

Peptide synthesis can be used for elucidating the roles of secondary structures in the specificity of hormones, antigens, and toxins. Intermediate sized peptides with these activities assume amphiphilic secondary structures in the presence of membranes. When models are designed to optimize the amphiphilicity of the secondary structure, stronger interactions can be observed with the synthetic peptides than with the naturally occurring analogs.

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Year: 1984 PMID： 6322295 DOI： 10.1126/science.6322295

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

71 in total

1. Hydrophobic hydration of amphipathic peptides.

Authors: Y K Cheng; W S Sheu; P J Rossky
Journal: Biophys J Date: 1999-04 Impact factor: 4.033

2. Oligoclonal antibody targeting ghrelin increases energy expenditure and reduces food intake in fasted mice.

Authors: Joseph S Zakhari; Eric P Zorrilla; Bin Zhou; Alexander V Mayorov; Kim D Janda
Journal: Mol Pharm Date: 2011-12-23 Impact factor: 4.939

3. Molecular characterization of antigen B2 subunit in two genotypes of Echinococcus granulosus from Indian bubaline isolates, its stage specific expression and serological evaluation.

Authors: D Pan; A K Bera; S Bandyopadhyay; S Das; T Rana; S K Das; S Bandyopadhyay; B Manna; D Bhattacharya
Journal: Mol Biol Rep Date: 2010-09-18 Impact factor: 2.316

Review 4. Opioid glycopeptide analgesics derived from endogenous enkephalins and endorphins.

Authors: Yingxue Li; Mark R Lefever; Dhanasekaran Muthu; Jean M Bidlack; Edward J Bilsky; Robin Polt
Journal: Future Med Chem Date: 2012-02 Impact factor: 3.808

5. Peptides related to the carboxyl terminus of human platelet factor IV with antibacterial activity.

Authors: R P Darveau; J Blake; C L Seachord; W L Cosand; M D Cunningham; L Cassiano-Clough; G Maloney
Journal: J Clin Invest Date: 1992-08 Impact factor: 14.808

6. Design and biological activity of analogs of growth hormone releasing factor with potential amphiphilic helical carboxyl termini.

Authors: G Veliçelebi; S Patthi; E T Kaiser
Journal: Proc Natl Acad Sci U S A Date: 1986-08 Impact factor: 11.205

Amphiphilic secondary structure: design of peptide hormones.

1. Hydrophobic hydration of amphipathic peptides.

2. Oligoclonal antibody targeting ghrelin increases energy expenditure and reduces food intake in fasted mice.

3. Molecular characterization of antigen B2 subunit in two genotypes of Echinococcus granulosus from Indian bubaline isolates, its stage specific expression and serological evaluation.

Review 4. Opioid glycopeptide analgesics derived from endogenous enkephalins and endorphins.

5. Peptides related to the carboxyl terminus of human platelet factor IV with antibacterial activity.

6. Design and biological activity of analogs of growth hormone releasing factor with potential amphiphilic helical carboxyl termini.

7. Mass-weighted molecular dynamics simulation and conformational analysis of polypeptide.

8. T-cell antigenic sites tend to be amphipathic structures.

9. Secondary structure characteristics of proenkephalin peptides E, B, and F.

10. Harnessing natures ability to control metal ion coordination geometry using de novo designed peptides.