Literature DB >> 6321918

The Na,K-ATPase hypothesis for manic-depression. I. General considerations.

R S el-Mallakh.   

Abstract

An hypothesis is presented to explain and integrate experimental and clinical observations on manic-depressive (bipolar or biphasic) psychosis. The model is based on alterations in the activity of the sodium, potassium-activated adenosine triphosphatase (Na, K-ATPase) pump. A reduction in the activity of the Na,K-ATPase can be responsible for both phases of the disorder.

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Year:  1983        PMID： 6321918     DOI： 10.1016/0306-9877(83)90042-7

Source DB:  PubMed          Journal:  Med Hypotheses        ISSN： 0306-9877            Impact factor:   1.538


  3 in total

1.  Na+/K+-ATPase level and products of lipid peroxidation in live cells treated with therapeutic lithium for different periods in time (1, 7, and 28 days); studies of Jurkat and HEK293 cells.

Authors:  Miroslava Vosahlikova; Lenka Roubalova; Hana Ujcikova; Martina Hlouskova; Stanislav Musil; Martin Alda; Petr Svoboda
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2019-02-21       Impact factor: 3.000

2.  Validation of the animal model of bipolar disorder induced by Ouabain: face, construct and predictive perspectives.

Authors:  Samira S Valvassori; Gustavo C Dal-Pont; Wilson R Resende; Roger B Varela; Jéssica Lopes-Borges; José Henrique Cararo; João Quevedo
Journal:  Transl Psychiatry       Date:  2019-06-04       Impact factor: 6.222

3.  Activating SIRT-1 Signalling with the Mitochondrial-CoQ10 Activator Solanesol Improves Neurobehavioral and Neurochemical Defects in Ouabain-Induced Experimental Model of Bipolar Disorder.

Authors:  Bidisha Rajkhowa; Sidharth Mehan; Pranshul Sethi; Aradhana Prajapati; Manisha Suri; Sumit Kumar; Sonalika Bhalla; Acharan S Narula; Abdulrahman Alshammari; Metab Alharbi; Nora Alkahtani; Saeed Alghamdi; Reni Kalfin
Journal:  Pharmaceuticals (Basel)       Date:  2022-08-02
  3 in total

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