| Literature DB >> 6321651 |
Abstract
The intracellular generation of reactive forms of reduced oxygen, namely, hydrogen peroxide, superoxide and hydroxyl radical, can damage dopamine neurons. Oxy-radicals, and hydrogen peroxide generated by monoamine oxidase, can contribute to increased rates of senescence of dopamine neurons in Parkinson's disease. The evidence that oxy-radicals and monoamine oxidase are potentially cytotoxic is reviewed, and a pathobiology of dopamine neuron senescence in Parkinson's disease is proposed.Entities:
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Year: 1983 PMID： 6321651
Source DB: PubMed Journal: J Neural Transm Suppl ISSN： 0303-6995