Literature DB >> 6321509

Toxicity testing of pertussis vaccines: effect of increased sensitivity of mice to Bordetella pertussis.

J Cameron, Y Desormeaux, M L De Bellefeuille, J Leclerc.   

Abstract

The increased sensitivity to Bordetella pertussis of a line of CD-1 mice used in toxicity-testing and the consequent and needless rejection of several lots of DPT vaccine are described. Apart from changes in the mice the possible presence of an infective agent in the animal house could not be discounted. The usefulness of individual mouse weights in the assay as opposed to group weights and of a reference preparation to monitor the performance of mice is discussed.

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Year:  1984        PMID: 6321509     DOI: 10.1016/s0092-1157(84)80017-7

Source DB:  PubMed          Journal:  J Biol Stand        ISSN: 0092-1157


  1 in total

1.  Study on Toxicity Reduction and Potency Induction in Whole-cell Pertussis Vaccine by Developing a New Optimal Inactivation Condition Processed on Bordetella pertussis.

Authors:  Naser Mohammadpour Dounighi; Mehdi Razzaghi-Abyane; Mojtaba Nofeli; Hossein Zolfagharian; Fereshteh Shahcheraghi
Journal:  Jundishapur J Microbiol       Date:  2016-07-09       Impact factor: 0.747

  1 in total

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