Literature DB >> 6321222

Reduced spinal reflexes following intrathecal baclofen in the rabbit.

J S Kroin, R D Penn, R L Beissinger, R C Arzbaecher.   

Abstract

Intrathecal baclofen is effective in reducing polysynaptic spinal reflexes in awake rabbits. A single lumbar infusion of 2.5-5.0 ng drug caused a significant reduction in the crossed extensor response to electrical stimulation of the plantar surface of the hindlimb. This inhibition lasted 5 h or more. At doses of 3 micrograms or less, the forelimbs were unaffected.

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Year:  1984        PMID： 6321222     DOI： 10.1007/bf00235831

Source DB:  PubMed          Journal:  Exp Brain Res        ISSN： 0014-4819            Impact factor:   1.972


  8 in total

1.  Flexion-reflex of the limb, crossed extension-reflex, and reflex stepping and standing.

Authors:  C S Sherrington
Journal:  J Physiol       Date:  1910-04-26       Impact factor: 5.182

2.  The chemistry and kinetics of Lioresal.

Authors:  J W Faigle; H Keberle
Journal:  Postgrad Med J       Date:  1972-10       Impact factor: 2.401

3.  Baclofen is antinociceptive in the spinal intrathecal space of animals.

Authors:  P R Wilson; T L Yaksh
Journal:  Eur J Pharmacol       Date:  1978-10-15       Impact factor: 4.432

4.  Plasma and cerebrospinal fluid levels of baclofen (Lioresal) at optimal therapeutic responses in spastic paresis.

Authors:  E Knutsson; U Lindblom; A Mårtensson
Journal:  J Neurol Sci       Date:  1974-11       Impact factor: 3.181

5.  Studies in the primate on the analgetic effects associated with intrathecal actions of opiates, alpha-adrenergic agonists and baclofen.

Authors:  T L Yaksh; S V Reddy
Journal:  Anesthesiology       Date:  1981-06       Impact factor: 7.892

6.  Chronic catheterization of the spinal subarachnoid space.

Authors:  T L Yaksh; T A Rudy
Journal:  Physiol Behav       Date:  1976-12

7.  The depressant action of baclofen on the isolated spinal cord of the neonatal rat.

Authors:  B Ault; R H Evans
Journal:  Eur J Pharmacol       Date:  1981-05-22       Impact factor: 4.432

8.  The effects of substance P and baclofen on motoneurones of isolated spinal cord of the newborn rat.

Authors:  M Otsuka; M Yanagisawa
Journal:  J Exp Biol       Date:  1980-12       Impact factor: 3.312
  8 in total
  5 in total

Review 1.  Intrathecal drug administration. Present use and future trends.

Authors:  J S Kroin
Journal:  Clin Pharmacokinet       Date:  1992-05       Impact factor: 6.447

2.  Lasting reduction of severe spasticity after ending chronic treatment with intrathecal baclofen.

Authors:  J Dressnandt; B Conrad
Journal:  J Neurol Neurosurg Psychiatry       Date:  1996-02       Impact factor: 10.154

3.  Intrathecal baclofen for long-term treatment of spasticity: a multi-centre study.

Authors:  G Ochs; A Struppler; B A Meyerson; B Linderoth; J Gybels; B P Gardner; P Teddy; A Jamous; P Weinmann
Journal:  J Neurol Neurosurg Psychiatry       Date:  1989-08       Impact factor: 10.154

4.  Intraspinal baclofen in the treatment of severe spasticity and spasms.

Authors:  J Sahuquillo; T Muxi; M Noguer; R Jodar; C Closa; E Rubio; L Garcia-Fernandez; J M Guitart
Journal:  Acta Neurochir (Wien)       Date:  1991       Impact factor: 2.216

5.  Delta-aminovaleric acid antagonizes the pharmacological actions of baclofen in the central nervous system.

Authors:  M Schwarz; T Klockgether; U Wüllner; L Turski; K H Sontag
Journal:  Exp Brain Res       Date:  1988       Impact factor: 1.972
  5 in total

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