Literature DB >> 6321085

Polymorphisms in the 5'-flanking region of the insulin gene and non-insulin-dependent diabetes.

G A Hitman, N I Jowett, L G Williams, S Humphries, R M Winter, D J Galton.   

Abstract

DNA insertions in the 5'-flanking region of the insulin gene have been studied by Southern-blot-hybridization techniques using a cloned gene probe in 159 unrelated Caucasians. Subjects homozygous for a large DNA insertion at this locus were found to have a higher risk of concurrence of non-insulin-dependent diabetes (NIDD) than controls (P less than 0.01). Analysis of a single large NIDD pedigree (n = 67 in four generations; 11 diabetic subjects) showed no linkage between the size of DNA inserts and diabetes (Lod score = -5.7), suggesting a separate diabetogenic locus (or loci) in this family.

Entities:  

Mesh：

Substances：

Year:  1984        PMID： 6321085     DOI： 10.1042/cs0660383

Source DB:  PubMed          Journal:  Clin Sci (Lond)        ISSN： 0143-5221            Impact factor:   6.124


  15 in total

1.  Multipoint linkage analysis of the short arm of chromosome 11 in non-insulin dependent diabetes including maturity onset diabetes of youth.

Authors:  S O'Rahilly; P Patel; O J Lehmann; A Tybjaerg-Hansen; J Nerup; R C Turner; J S Wainscoat
Journal:  Hum Genet       Date:  1992-05       Impact factor: 4.132

2.  Affected sib-pair analysis of the GLUT1 glucose transporter gene locus in non-insulin-dependent diabetes mellitus (NIDDM): evidence for no linkage.

Authors:  M G Baroni; J C Alcolado; C Gragnoli; A M Franciosi; M G Cavallo; V Fiore; P Pozzilli; D J Galton
Journal:  Hum Genet       Date:  1994-06       Impact factor: 4.132

3.  Allelic variation adjacent to the human insulin and apolipoprotein C-II genes in different ethnic groups.

Authors:  L G Williams; N I Jowett; M A Vella; S Humphries; D J Galton
Journal:  Hum Genet       Date:  1985       Impact factor: 4.132

Review 4.  DNA polymorphism and the study of disease associations.

Authors:  D N Cooper; J F Clayton
Journal:  Hum Genet       Date:  1988-04       Impact factor: 4.132

5.  Genetic analysis of the hypervariable region flanking the human insulin gene.

Authors:  P Rotwein; S Yokoyama; D K Didier; J M Chirgwin
Journal:  Am J Hum Genet       Date:  1986-09       Impact factor: 11.025

Review 6.  Type 2 (non-insulin-dependent) diabetes mellitus. New genetics for old nightmares.

Authors:  S O'Rahilly; J S Wainscoat; R C Turner
Journal:  Diabetologia       Date:  1988-07       Impact factor: 10.122

Review 7.  Do genetic factors play a role in the pathogenesis of diabetic microangiopathy?

Authors:  J Barbosa; B Saner
Journal:  Diabetologia       Date:  1984-11       Impact factor: 10.122

8.  Linkage analysis of the human insulin receptor gene in type 2 (non-insulin-dependent) diabetic families and a family with maturity onset diabetes of the young.

Authors:  S O'Rahilly; R C Trembath; P Patel; D J Galton; R C Turner; J S Wainscoat
Journal:  Diabetologia       Date:  1988-11       Impact factor: 10.122

9.  Large-scale studies of the HphI insulin gene variable-number-of-tandem-repeats polymorphism in relation to Type 2 diabetes mellitus and insulin release.

Authors:  S K Hansen; A P Gjesing; S K Rasmussen; C Glümer; S A Urhammer; G Andersen; C S Rose; T Drivsholm; S K Torekov; D P Jensen; C T Ekstrøm; K Borch-Johnsen; T Jørgensen; M I McCarthy; T Hansen; O Pedersen
Journal:  Diabetologia       Date:  2004-05-29       Impact factor: 10.122

10.  HLA class II alpha chain gene polymorphisms in patients with insulin-dependent diabetes mellitus, dermatitis herpetiformis, and celiac disease.

Authors:  G A Hitman; M J Niven; H Festenstein; P G Cassell; J Awad; J Walker-Smith; J N Leonard; L Fry; P Ciclitira; P Kumar
Journal:  J Clin Invest       Date:  1987-02       Impact factor: 14.808
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.