Literature DB >> 6320799

The subcellular localization of ubiquinone in human neutrophils.

A R Cross, O T Jones, R Garcia, A W Segal.   

Abstract

Ubiquinone-10 has recently been proposed as a component of the microbicidal oxidase system of neutrophil leukocytes [Crawford & Schneider (1982) J. Biol. Chem. 257, 6662-6668]. We have determined the subcellular localization of ubiquinone and could detect it only in the mitochondrial fractions. It was not enriched in phagolysosomes which were enriched in O2-. generating activity and cytochrome b-245. It is proposed that ubiquinone is unlikely to play a direct role in the electron transport chain located in the plasma membrane which functions to produce microbicidal oxygen radicals.

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Year:  1983        PMID： 6320799      PMCID： PMC1152573          DOI： 10.1042/bj2160765

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  21 in total

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Journal:  Enzyme       Date:  1972

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Authors:  D R Light; C Walsh; A M O'Callaghan; E J Goetzl; A I Tauber
Journal:  Biochemistry       Date:  1981-03-17       Impact factor: 3.162

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Journal:  FEBS Lett       Date:  1980-02-11       Impact factor: 4.124

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Authors:  A W Segal; O T Jones
Journal:  Nature       Date:  1978-11-30       Impact factor: 49.962

8.  The O2(-) -forming oxidase responsible for the respiratory burst in human neutrophils. Properties of the solubilized enzyme.

Authors:  T G Gabig; B M Babior
Journal:  J Biol Chem       Date:  1979-09-25       Impact factor: 5.157

9.  The subcellular distribution and some properties of the cytochrome b component of the microbicidal oxidase system of human neutrophils.

Authors:  A W Segal; O T Jones
Journal:  Biochem J       Date:  1979-07-15       Impact factor: 3.857

10.  The isolation from rat peritoneal leukocytes of plasma membrane enriched in alkaline phosphatase and a B-type cytochrome.

Authors:  J A Millard; K W Gerard; D L Schneider
Journal:  Biochem Biophys Res Commun       Date:  1979-09-12       Impact factor: 3.575
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  10 in total

Review 1.  The electron transport chain of the microbicidal oxidase of phagocytic cells and its involvement in the molecular pathology of chronic granulomatous disease.

Authors:  A W Segal
Journal:  J Clin Invest       Date:  1989-06       Impact factor: 14.808

Review 2.  Phagocytes use oxygen to kill bacteria.

Authors:  M Baggiolini
Journal:  Experientia       Date:  1984-09-15

Review 3.  Subcellular localization and dynamics of components of the respiratory burst oxidase.

Authors:  N Borregaard
Journal:  J Bioenerg Biomembr       Date:  1988-12       Impact factor: 2.945

4.  Induction of synthesis of components of the hydrogen peroxide-generating oxidase during activation of the human monocytic cell line U937 by interferon-gamma.

Authors:  P W Andrew; A K Robertson; D B Lowrie; A R Cross; O T Jones
Journal:  Biochem J       Date:  1987-11-15       Impact factor: 3.857

5.  The inhibition by diphenyleneiodonium and its analogues of superoxide generation by macrophages.

Authors:  J T Hancock; O T Jones
Journal:  Biochem J       Date:  1987-02-15       Impact factor: 3.857

6.  NADPH oxidase of guinea-pig macrophages catalyses the reduction of ubiquinone-1 under anaerobic conditions.

Authors:  M Murakami; M Nakamura; S Minakami
Journal:  Biochem J       Date:  1986-07-15       Impact factor: 3.857

7.  Composition of partially purified NADPH oxidase from pig neutrophils.

Authors:  P Bellavite; O T Jones; A R Cross; E Papini; F Rossi
Journal:  Biochem J       Date:  1984-11-01       Impact factor: 3.857

8.  NADPH-binding component of the superoxide-generating oxidase in unstimulated neutrophils and the neutrophils from the patients with chronic granulomatous disease.

Authors:  T Umei; K Takeshige; S Minakami
Journal:  Biochem J       Date:  1987-04-15       Impact factor: 3.857

Review 9.  The NADPH oxidase of professional phagocytes--prototype of the NOX electron transport chain systems.

Authors:  Andrew R Cross; Anthony W Segal
Journal:  Biochim Biophys Acta       Date:  2004-06-28

10.  Prepartal Energy Intake Alters Blood Polymorphonuclear Leukocyte Transcriptome During the Peripartal Period in Holstein Cows.

Authors:  A Agrawal; M J Khan; D E Graugnard; M Vailati-Riboni; S L Rodriguez-Zas; J S Osorio; J J Loor
Journal:  Bioinform Biol Insights       Date:  2017-04-28
  10 in total

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