Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Estimation of the marker gene frequency and linkage disequilibrium from conditional marker data.

Literature DB >> 6320641

Estimation of the marker gene frequency and linkage disequilibrium from conditional marker data.

Abstract

A method is proposed to calculate the maximum likelihood estimate of gene frequency and linkage disequilibrium from disease-codominant marker conditional data. The method is illustrated using data on sickle-cell anemia and Duchenne muscular dystrophy and linked polymorphic restriction endonuclease cleavage sites.

Entities: Disease

Mesh：

Substances：

Year: 1984 PMID： 6320641 PMCID： PMC1684398

Source DB: PubMed Journal: Am J Hum Genet ISSN： 0002-9297 Impact factor: 11.025

11 in total

1. Proportion of informative families for genetic counseling with linked marker genes.

Authors: M Nei
Journal: Jinrui Idengaku Zasshi Date: 1979-09

2. Heterogeneity of DNA fragments associated with the sickle-globin gene.

Authors: J Feldenzer; J G Mears; A L Burns; C Natta; A Bank
Journal: J Clin Invest Date: 1979-09 Impact factor: 14.808

3. Estimation of linkage disequilibrium in randomly mating populations.

Authors: W G Hill
Journal: Heredity (Edinb) Date: 1974-10 Impact factor: 3.821

4. Genetic diagnosis of the fetus.

Authors: S H Orkin
Journal: Nature Date: 1982-03-18 Impact factor: 49.962

5. Linkage relationship of a cloned DNA sequence on the short arm of the X chromosome to Duchenne muscular dystrophy.

Authors: J M Murray; K E Davies; P S Harper; L Meredith; C R Mueller; R Williamson
Journal: Nature Date: 1982-11-04 Impact factor: 49.962

6. Evolution of the hemoglobin S and C genes in world populations.

Authors: Y W Kan; A M Dozy
Journal: Science Date: 1980-07-18 Impact factor: 47.728

7. Utility and efficiency of linked marker genes for genetic counseling. III. Proportion of informative families under linkage disequilibrium.

Authors: A Chakravarti
Journal: Am J Hum Genet Date: 1983-07 Impact factor: 11.025

8. Polymorphism of DNA sequence adjacent to human beta-globin structural gene: relationship to sickle mutation.

Authors: Y W Kan; A M Dozy
Journal: Proc Natl Acad Sci U S A Date: 1978-11 Impact factor: 11.205

9. Population heterogeneity of the Hpa I restriction site associated with the beta globin gene: implications for prenatal diagnosis.

Authors: S R Panny; A F Scott; K D Smith; J A Phillips; H H Kazazian; C C Talbot; C D Boehm
Journal: Am J Hum Genet Date: 1981-01 Impact factor: 11.025

Review 10. Construction of a genetic linkage map in man using restriction fragment length polymorphisms.

Authors: D Botstein; R L White; M Skolnick; R W Davis
Journal: Am J Hum Genet Date: 1980-05 Impact factor: 11.025

12 in total

1. Expected behavior of conditional linkage disequilibrium.

Authors: N Kaplan; B S Weir
Journal: Am J Hum Genet Date: 1992-08 Impact factor: 11.025

2. Estimating linkage disequilibrium from conditional data.

Authors: P J Maiste; B S Weir
Journal: Am J Hum Genet Date: 1992-05 Impact factor: 11.025

3. Analysis of DNA polymorphism haplotypes linked to the cystic fibrosis locus in North American black and Caucasian families supports the existence of multiple mutations of the cystic fibrosis gene.

Authors: G R Cutting; S E Antonarakis; K H Buetow; L M Kasch; B J Rosenstein; H H Kazazian
Journal: Am J Hum Genet Date: 1989-03 Impact factor: 11.025

Estimation of the marker gene frequency and linkage disequilibrium from conditional marker data.

1. Proportion of informative families for genetic counseling with linked marker genes.

2. Heterogeneity of DNA fragments associated with the sickle-globin gene.

3. Estimation of linkage disequilibrium in randomly mating populations.

4. Genetic diagnosis of the fetus.

5. Linkage relationship of a cloned DNA sequence on the short arm of the X chromosome to Duchenne muscular dystrophy.

6. Evolution of the hemoglobin S and C genes in world populations.

7. Utility and efficiency of linked marker genes for genetic counseling. III. Proportion of informative families under linkage disequilibrium.

8. Polymorphism of DNA sequence adjacent to human beta-globin structural gene: relationship to sickle mutation.

9. Population heterogeneity of the Hpa I restriction site associated with the beta globin gene: implications for prenatal diagnosis.

Review 10. Construction of a genetic linkage map in man using restriction fragment length polymorphisms.

1. Expected behavior of conditional linkage disequilibrium.

2. Estimating linkage disequilibrium from conditional data.

3. Analysis of DNA polymorphism haplotypes linked to the cystic fibrosis locus in North American black and Caucasian families supports the existence of multiple mutations of the cystic fibrosis gene.

4. The use of multiple restriction fragment length polymorphisms in prenatal risk estimation. I. X-linked diseases.

5. A strategy for using multiple linked markers for genetic counseling.

6. Conditional asymmetric linkage disequilibrium (ALD): extending the biallelic r2 measure.

7. Detection of marker associations with a dominant disease gene in genetically complex and heterogeneous diseases.

8. Linkage disequilibrium of plasminogen polymorphisms and assignment of the gene to human chromosome 6q26-6q27.

9. Linkage disequilibrium in the neurofibromatosis 1 (NF1) region: implications for gene mapping.

10. Microsatellite diversity among the primitive tribes of India.