Literature DB >> 6320017

Two configurations of a channel-forming membrane protein.

P N Unwin, P D Ennis.   

Abstract

The protein oligomer forming the gap junction channel has been analysed in two Ca2+-sensitive states by electron microscopy of membranes in frozen aqueous solutions. Switching between states occurs by a small cooperative rearrangement involving tilting of the subunits, which may be responsible for the effect of Ca2+ on channel permeability in vivo.

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Year:  1984        PMID: 6320017     DOI: 10.1038/307609a0

Source DB:  PubMed          Journal:  Nature        ISSN: 0028-0836            Impact factor:   49.962


  91 in total

1.  Inclusion-induced bilayer deformations: effects of monolayer equilibrium curvature.

Authors:  C Nielsen; O S Andersen
Journal:  Biophys J       Date:  2000-11       Impact factor: 4.033

Review 2.  Controlling potassium channel activities: Interplay between the membrane and intracellular factors.

Authors:  B A Yi; D L Minor; Y F Lin; Y N Jan; L Y Jan
Journal:  Proc Natl Acad Sci U S A       Date:  2001-09-25       Impact factor: 11.205

3.  Conformational changes in surface structures of isolated connexin 26 gap junctions.

Authors:  Daniel J Müller; Galen M Hand; Andreas Engel; Gina E Sosinsky
Journal:  EMBO J       Date:  2002-07-15       Impact factor: 11.598

4.  Atomic force microscopy of three-dimensional membrane protein crystals. Ca-ATPase of sarcoplasmic reticulum.

Authors:  J J Lacapère; D L Stokes; D Chatenay
Journal:  Biophys J       Date:  1992-08       Impact factor: 4.033

Review 5.  Structural basis for the selective permeability of channels made of communicating junction proteins.

Authors:  Jose F Ek-Vitorin; Janis M Burt
Journal:  Biochim Biophys Acta       Date:  2012-02-10

6.  Gating of connexin 43 gap junctions by a cytoplasmic loop calmodulin binding domain.

Authors:  Qin Xu; Richard F Kopp; Yanyi Chen; Jenny J Yang; Michael W Roe; Richard D Veenstra
Journal:  Am J Physiol Cell Physiol       Date:  2012-03-14       Impact factor: 4.249

Review 7.  Voltage-dependent conformational changes in connexin channels.

Authors:  Thaddeus A Bargiello; Qingxiu Tang; Seunghoon Oh; Taekyung Kwon
Journal:  Biochim Biophys Acta       Date:  2011-09-24

Review 8.  Connexins and the kidney.

Authors:  Fiona Hanner; Charlotte Mehlin Sorensen; Niels-Henrik Holstein-Rathlou; János Peti-Peterdi
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2010-02-17       Impact factor: 3.619

Review 9.  Identification and characterization of a pregnane steroid recognition site that is functionally coupled to an expressed GABAA receptor.

Authors:  N C Lan; M B Bolger; K W Gee
Journal:  Neurochem Res       Date:  1991-03       Impact factor: 3.996

10.  Quantitative gap junction alterations in mammalian heart cells quickly frozen or chemically fixed after electrical uncoupling.

Authors:  J Délèze; J C Hervé
Journal:  J Membr Biol       Date:  1986       Impact factor: 1.843

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