| Literature DB >> 6319894 |
M J Kreek, S L Wardlaw, N Hartman, J Raghunath, J Friedman, B Schneider, A G Frantz.
Abstract
Previous studies have shown alterations of neuroendocrine function in humans receiving any narcotic on short-term basis or short-acting narcotics on a chronic basis. In this study of 16 well-stabilized patients, it was demonstrated that normalization of hypothalamic-pituitary-adrenal axis function, as reflected by normal levels and normal circadian rhythm of levels of beta-endorphin, ACTH and cortisol, is achieved during long-term steady state methadone maintenance treatment of former heroin addicts.Entities:
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Year: 1983 PMID： 6319894 DOI： 10.1016/0024-3205(83)90529-5
Source DB: PubMed Journal: Life Sci ISSN： 0024-3205 Impact factor: 5.037