Literature DB >> 6319194

Evidence that helodermin, a newly extracted peptide from Gila monster venom, is a member of the secretin/VIP/PHI family of peptides with an original pattern of biological properties.

P Robberecht, M Waelbroeck, J P Dehaye, J Winand, A Vandermeers, M C Vandermeers-Piret, J Christophe.   

Abstract

Helodermin, a newly isolated peptide from the venom of Gila monster (Heloderma suspectum) was shown to stimulate the adenylate cyclase activity of rat pancreatic membranes as efficiently as secretin and VIP. It also increased cyclic AMP levels and inhibited [125I]VIP binding in rat pancreatic acini. Finally, helodermin activated adenylate cyclase in membranes from rat heart, rat brain, and human heart, showing properties analogous yet distinct from those of secretin, VIP and PHI.

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Year:  1984        PMID： 6319194     DOI： 10.1016/0014-5793(84)80095-2

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  7 in total

1.  Helodermin and islet hormone release in isolated rat pancreas.

Authors:  H C Fehmann; R Göke; B Göke; R Eissele; R Arnold
Journal:  Int J Pancreatol       Date:  1991-05

2.  Helodermin, helospectin, and PACAP stimulate cyclic AMP formation in intact bone, isolated osteoblasts, and osteoblastic cell lines.

Authors:  U H Lerner; P Lundberg; M Ransjö; P Persson; R Håkanson
Journal:  Calcif Tissue Int       Date:  1994-04       Impact factor: 4.333

3.  Helodermin-like peptides in thyroid C cells: stimulation of thyroid hormone secretion and suppression of calcium incorporation into bone.

Authors:  T Grunditz; P Persson; R Håkanson; A Absood; G Böttcher; C Rerup; F Sundler
Journal:  Proc Natl Acad Sci U S A       Date:  1989-02       Impact factor: 11.205

4.  Mast cell chymase reduces the toxicity of Gila monster venom, scorpion venom, and vasoactive intestinal polypeptide in mice.

Authors:  Mitsuteru Akahoshi; Chang Ho Song; Adrian M Piliponsky; Martin Metz; Andrew Guzzetta; Magnus Abrink; Susan M Schlenner; Thorsten B Feyerabend; Hans-Reimer Rodewald; Gunnar Pejler; Mindy Tsai; Stephen J Galli
Journal:  J Clin Invest       Date:  2011-09-19       Impact factor: 14.808

5.  Crystal structure of the PAC1R extracellular domain unifies a consensus fold for hormone recognition by class B G-protein coupled receptors.

Authors:  Shiva Kumar; Augen Pioszak; Chenghai Zhang; Kunchithapadam Swaminathan; H Eric Xu
Journal:  PLoS One       Date:  2011-05-19       Impact factor: 3.240

Review 6.  Targeting VIP and PACAP Receptor Signaling: New Insights into Designing Drugs for the PACAP Subfamily of Receptors.

Authors:  Jessica Lu; Sarah J Piper; Peishen Zhao; Laurence J Miller; Denise Wootten; Patrick M Sexton
Journal:  Int J Mol Sci       Date:  2022-07-22       Impact factor: 6.208

7.  Helodermatine, a kallikrein-like, hypotensive enzyme from the venom of Heloderma horridum horridum (Mexican beaded lizard).

Authors:  A Alagon; L D Possani; J Smart; W D Schleuning
Journal:  J Exp Med       Date:  1986-12-01       Impact factor: 14.307
  7 in total

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