| Literature DB >> 6319181 |
M R Attwood, R J Francis, C H Hassall, A Kröhn, G Lawton, I L Natoff, J S Nixon, S Redshaw, W A Thomas.
Abstract
Using an earlier model of the favoured orientation of binding functions of angiotensin converting enzyme (ACE) inhibitors, it has been possible to postulate a new, 7,6-bicyclic system, based on hexahydropyridazine, which might be expected to have high potency. Some members of this system which have been synthesised have been shown to be very active ACE inhibitors, in vitro and in vivo.Entities:
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Year: 1984 PMID： 6319181 DOI： 10.1016/0014-5793(84)80169-6
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124