Literature DB >> 6319012

Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22.

J Groffen, J R Stephenson, N Heisterkamp, A de Klein, C R Bartram, G Grosveld.   

Abstract

We have identified and molecularly cloned 46 kb of human DNA from chromosome 22 using a probe specific for the Philadelphia (Ph') translocation breakpoint domain of one chronic myelocytic leukemia (CML) patient. The DNAs of 19 CML patients were examined for rearrangements on chromosome 22 with probes isolated from this cloned region. In 17 patients, chromosomal breakpoints were found within a limited region of up to 5.8 kb, for which we propose the term "breakpoint cluster region" (bcr). The two patients having no rearrangements within bcr lacked the Ph' chromosome. The highly specific presence of a chromosomal breakpoint within bcr in Ph'-positive CML patients strongly suggests the involvement of bcr in this type of leukemia.

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Year:  1984        PMID： 6319012     DOI： 10.1016/0092-8674(84)90077-1

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  286 in total

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Review 3.  Molecular biology in medicine.

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5.  Molecular biology of Philadelphia chromosome in chronic granulocytic leukaemia and acute lymphoblastic leukaemia.

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Journal:  Cytotechnology       Date:  1987-10       Impact factor: 2.058

6.  The spectrum of molecular alterations in the evolution of chronic myelocytic leukemia.

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7.  Expression of a Src family kinase in chronic myelogenous leukemia cells induces resistance to imatinib in a kinase-dependent manner.

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8.  Preliminary study on bcr rearrangement in leukemia.

Authors:  R M Jin; A D Yang; H B Fei
Journal:  J Tongji Med Univ       Date:  1994

9.  Tyrosine phosphorylation of Dbl regulates GTPase signaling.

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10.  Abr and Bcr are multifunctional regulators of the Rho GTP-binding protein family.

Authors:  T H Chuang; X Xu; V Kaartinen; N Heisterkamp; J Groffen; G M Bokoch
Journal:  Proc Natl Acad Sci U S A       Date:  1995-10-24       Impact factor: 11.205
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