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Literature DB >> 6318867

Functional properties of neoplastic T cells in adult T cell lymphoma/leukemia patients from the Caribbean.

F Miedema, F G Terpstra, J W Smit, S Daenen, W Gerrits, U Hegde, E Matutes, D Catovsky, M F Greaves, C J Melief.

Abstract

The neoplastic T cells from five patients with adult T cell lymphoma/leukemia (ATLL), born in the Caribbean, were studied with respect to immunoregulatory activity on pokeweed mitogen (PWM) driven immunoglobulin (Ig) synthesis as well as surface-marker phenotypes with monoclonal antibodies. The neoplastic T cells in all patients had an OKT1+4+8-11+M1-I1-3A1- phenotype, but differed in the reactivity with OKT3. None of the patients' cells exerted helper activity on PWM-induced Ig synthesis. The neoplastic cells of three patients had suppressor activity on PWM-induced Ig synthesis. All patients were positive for human T cell leukemia/lymphoma virus (HTLV) or had antibodies against HTLV antigens. It has previously been shown that the neoplastic cells in Japanese ATLL patients and in patients from the Caribbean are indistinguishable by morphology and marker phenotype. We now show them to be also similar with respect to their functional properties.

Entities: Disease Species

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Year: 1984 PMID： 6318867

Source DB: PubMed Journal: Blood ISSN： 0006-4971 Impact factor: 22.113

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Cited

8 in total

1. Analysis of helper activity on pokeweed mitogen- and interleukin 2-driven immunoglobulin synthesis by neoplastic T4+ cells.

Authors: F Miedema; J W van Oostveen; F G Terpstra; A W van den Wall Bake; R Willemze; E A Rauws; R Bieger; M B van 't Veer; D Catovsky; C J Melief
Journal: J Clin Invest Date: 1985-12 Impact factor: 14.808

2. Immunoglobulin subclasses of antibodies to human T-cell leukemia/lymphoma virus I-associated antigens in acquired immune deficiency syndrome and lymphadenopathy syndrome.

Authors: J Goudsmit; F Miedema; R J Wijngaarden-du Bois; M T Roos; P T Schellekens; R A Coutinho; J van der Noordaa; C J Melief
Journal: J Virol Date: 1985-01 Impact factor: 5.103

3. HTLV-1 seroprevalence in AIDS patients and in HIV-1 seropositive and seronegative subjects at risk for AIDS in northern Italy.

Authors: N Manca; A Caruso; C Bonfanti; E Savoldi; R Li Vigni; F Pirali; P L Sapelli; A Turano
Journal: Eur J Epidemiol Date: 1989-03 Impact factor: 8.082

Functional properties of neoplastic T cells in adult T cell lymphoma/leukemia patients from the Caribbean.

1. Analysis of helper activity on pokeweed mitogen- and interleukin 2-driven immunoglobulin synthesis by neoplastic T4+ cells.

2. Immunoglobulin subclasses of antibodies to human T-cell leukemia/lymphoma virus I-associated antigens in acquired immune deficiency syndrome and lymphadenopathy syndrome.

3. HTLV-1 seroprevalence in AIDS patients and in HIV-1 seropositive and seronegative subjects at risk for AIDS in northern Italy.

4. SIg-E- ("null-cell") non-Hodgkin's lymphomas. Multiparametric determination of their B- or T-cell lineage.

5. T gamma lymphocytosis is clinically non-progressive but immunologically heterogeneous.

Review 6. Immunophenotypic and antigen receptor gene rearrangement analysis in T cell neoplasia.

7. Functional and phenotypic studies of Japanese adult T cell leukemia cells.

8. Antibodies to HTLV-1-2, HIV-1 and HIV-2 in syphilitic patients.