| Literature DB >> 6318796 |
S L Thein, I Al-Hakim, A V Hoffbrand.
Abstract
A 5-year-old child heterozygous for beta thalassaemia has the clinical picture of thalassaemia intermedia. Restriction endonuclease mapping shows that the child is homozygous for a triplicated alpha gene complex. The greater degree of globin chain imbalance resulting from two additional alpha chain genes is the likely mechanism for this unusually severe clinical phenotype.Entities:
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Year: 1984 PMID： 6318796 DOI： 10.1111/j.1365-2141.1984.tb03960.x
Source DB: PubMed Journal: Br J Haematol ISSN： 0007-1048 Impact factor: 6.998